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Stem Cells International
Volume 2016, Article ID 5093725, 9 pages
http://dx.doi.org/10.1155/2016/5093725
Research Article

Isolation, Characterization, and Multipotent Differentiation of Mesenchymal Stem Cells Derived from Meniscal Debris

1Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China
2Department of Orthopedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Institute of Sports Medicine, Peking University Third Hospital, Beijing, China

Received 16 May 2016; Revised 22 September 2016; Accepted 6 November 2016

Academic Editor: Shiwu Dong

Copyright © 2016 Weili Fu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. B. Mandal, S.-H. Park, E. S. Gil, and D. L. Kaplan, “Stem cell-based meniscus tissue engineering,” Tissue Engineering—Part A, vol. 17, no. 21-22, pp. 2749–2761, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Angele, B. Johnstone, R. Kujat et al., “Stem cell based tissue engineering for meniscus repair,” Journal of Biomedical Materials Research Part A, vol. 85, no. 2, pp. 445–455, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. M. J. Salata, A. E. Gibbs, and J. K. Sekiya, “A systematic review of clinical outcomes in patients undergoing meniscectomy,” The American Journal of Sports Medicine, vol. 38, no. 9, pp. 1907–1916, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. E. S. Paxton, M. V. Stock, and R. H. Brophy, “Meniscal repair versus partial meniscectomy: a systematic review comparing reoperation rates and clinical outcomes,” Arthroscopy, vol. 27, no. 9, pp. 1275–1288, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Marcacci, S. Zaffagnini, G. M. Marcheggiani Muccioli et al., “Meniscal allograft transplantation without bone plugs: a 3-year minimum follow-up study,” The American Journal of Sports Medicine, vol. 40, no. 2, pp. 395–403, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Jiang, L.-H. Zhao, M. Tian, J.-Y. Zhang, and J.-K. Yu, “Meniscus transplantation using treated xenogeneic meniscal tissue: viability and chondroprotection study in rabbits,” Arthroscopy, vol. 28, no. 8, pp. 1147–1159, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Hasan, J. Fisher, and E. Ingham, “Current strategies in meniscal regeneration,” Journal of Biomedical Materials Research—Part B Applied Biomaterials, vol. 102, no. 3, pp. 619–634, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. W. Niu, W. Guo, S. Han et al., “Cell-based strategies for meniscus tissue engineering,” Stem Cells International, vol. 2016, Article ID 4717184, 10 pages, 2016. View at Publisher · View at Google Scholar
  9. C. Liu, I. C. Toma, M. Mastrogiacomo, C. Krettek, G. Von Lewinski, and M. Jagodzinski, “Meniscus reconstruction: today's achievements and premises for the future,” Archives of Orthopaedic and Trauma Surgery, vol. 133, no. 1, pp. 95–109, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. B. M. Baker, A. S. Nathan, G. R. Huffman, and R. L. Mauck, “Tissue engineering with meniscus cells derived from surgical debris,” Osteoarthritis and Cartilage, vol. 17, no. 3, pp. 336–345, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. N. J. Gunja and K. A. Athanasiou, “Passage and reversal effects on gene expression of bovine meniscal fibrochondrocytes,” Arthritis Research & Therapy, vol. 9, no. 5, article R93, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. G.-K. Tan, D. L. M. Dinnes, P. T. Myers, and J. J. Cooper-White, “Effects of biomimetic surfaces and oxygen tension on redifferentiation of passaged human fibrochondrocytes in 2D and 3D cultures,” Biomaterials, vol. 32, no. 24, pp. 5600–5614, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Bianco, P. G. Robey, and P. J. Simmons, “Mesenchymal stem cells: revisiting history, concepts, and assays,” Cell Stem Cell, vol. 2, no. 4, pp. 313–319, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Zellner, K. Hierl, M. Mueller et al., “Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone,” Journal of Biomedical Materials Research—Part B Applied Biomaterials, vol. 101, no. 7, pp. 1133–1142, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Agung, M. Ochi, S. Yanada et al., “Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration,” Knee Surgery, Sports Traumatology, Arthroscopy, vol. 14, no. 12, pp. 1307–1314, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Jiang, B. N. Jahagirdar, R. L. Reinhardt et al., “Pluripotency of mesenchymal stem cells derived from adult marrow,” Nature, vol. 418, no. 6893, pp. 41–49, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Wang, Z. Zhang, Y. Chi et al., “Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation,” Cell Death and Disease, vol. 4, no. 12, article e950, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. J. C. Estrada, Y. Torres, A. Benguría et al., “Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy,” Cell Death & Disease, vol. 4, article e691, 2013. View at Google Scholar · View at Scopus
  19. D. Rubio, S. Garcia, M. F. Paz et al., “Molecular characterization of spontaneous mesenchymal stem cell transformation,” PLoS ONE, vol. 3, no. 1, article e1398, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. W. Wagner, P. Horn, M. Castoldi et al., “Replicative senescence of mesenchymal stem cells: a continuous and organized process,” PLoS ONE, vol. 3, no. 5, article e2213, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. M. B. Mueller and R. S. Tuan, “Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells,” Arthritis and Rheumatism, vol. 58, no. 5, pp. 1377–1388, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Scotti, M. T. Hirschmann, P. Antinolfi, I. Martin, and G. M. Peretti, “Meniscus repair and regeneration: review on current methods and research potential,” European Cells and Materials, vol. 26, pp. 150–170, 2013. View at Google Scholar · View at Scopus
  23. R. L. Mauck, X. Yuan, and R. S. Tuan, “Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture,” Osteoarthritis and Cartilage, vol. 14, no. 2, pp. 179–189, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Bieback, S. Kern, A. Kocaömer, K. Ferlik, and P. Bugert, “Comparing mesenchymal stromal cells from different human tissues: bone marrow, adipose tissue and umbilical cord blood,” Bio-Medical Materials and Engineering, vol. 18, no. 1, pp. S71–S76, 2008. View at Google Scholar · View at Scopus
  25. A. N. Patel, E. Park, M. Kuzman, F. Benetti, F. J. Silva, and J. G. Allickson, “Multipotent menstrual blood stromal stem cells: isolation, characterization, and differentiation,” Cell Transplantation, vol. 17, no. 3, pp. 303–311, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Pak, J. H. Lee, and S. H. Lee, “Regenerative repair of damaged meniscus with autologous adipose tissue-derived stem cells,” BioMed Research International, vol. 2014, Article ID 436029, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Tan, Y. Zhang, and M. Pei, “Meniscus reconstruction through coculturing meniscus cells with synovium-derived stem cells on small intestine submucosa—a pilot study to engineer meniscus tissue constructs,” Tissue Engineering—Part A, vol. 16, no. 1, pp. 67–79, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. R. L. Mauck, G. J. Martinez-Diaz, X. Yuan, and R. S. Tuan, “Regional multilineage differentiation potential of meniscal fibrochondrocytes: implications for meniscus repair,” Anatomical Record, vol. 290, no. 1, pp. 48–58, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Segawa, T. Muneta, H. Makino et al., “Mesenchymal stem cells derived from synovium, meniscus, anterior cruciate ligament, and articular chondrocytes share similar gene expression profiles,” Journal of Orthopaedic Research, vol. 27, no. 4, pp. 435–441, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. M. F. Pittenger, A. M. Mackay, S. C. Beck et al., “Multilineage potential of adult human mesenchymal stem cells,” Science, vol. 284, no. 5411, pp. 143–147, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. S. B. Adams Jr., G. M. Peretti, C. Weinand et al., “Meniscal repair: current strategies and the future of tissue engineering,” The Orthopaedic Journal at Harvard Medical School, vol. 5, pp. 138–141, 2003. View at Google Scholar
  32. Y. Matsukura, T. Muneta, K. Tsuji, H. Koga, and I. Sekiya, “Mesenchymal stem cells in synovial fluid increase after meniscus injury,” Clinical Orthopaedics and Related Research, vol. 472, no. 5, pp. 1357–1364, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Morito, T. Muneta, K. Hara et al., “Synovial fluid-derived mesenchymal stem cells increase after intra-articular ligament injury in humans,” Rheumatology, vol. 47, no. 8, pp. 1137–1143, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Roberts, D. Mauerhan, and Y. Sun, “The role of meniscal cells in osteoarthritis calcification,” Arthritis & Rheumatology, vol. 65, pp. S33–S34, 2013. View at Google Scholar
  35. L. Peng, Z. Jia, X. Yin et al., “Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue,” Stem Cells and Development, vol. 17, no. 4, pp. 761–773, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. Y. Sun and D. R. Mauerhan, “Meniscal calcification, pathogenesis and implications,” Current Opinion in Rheumatology, vol. 24, no. 2, pp. 152–157, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Sun, D. R. Mauerhan, P. R. Honeycutt et al., “Calcium deposition in osteoarthritic meniscus and meniscal cell culture,” Arthritis Research and Therapy, vol. 12, no. 2, article R56, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. W. Shen, J. Chen, T. Zhu et al., “Intra-articular injection of human meniscus stem/progenitor cells promotes meniscus regeneration and ameliorates osteoarthritis through stromal cell-derived factor-1/CXCR4-mediated homing,” Stem Cells Translational Medicine, vol. 3, no. 3, pp. 387–394, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. W. Shen, J. Chen, T. Zhu et al., “Osteoarthritis prevention through meniscal regeneration induced by intra-articular injection of meniscus stem cells,” Stem Cells and Development, vol. 22, no. 14, pp. 2071–2082, 2013. View at Publisher · View at Google Scholar · View at Scopus