Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function

Figure 1

Hematopoietic stem cells maintain quiescence through extrinsic and intrinsic signals. The stem cell niche provides signals that regulate HSC quiescence and localization in the niche. DL1 and Notch; CXCL12 and CXCR4; and Wnt and Frizzled. HSC intrinsic transcription factors regulate signaling process to keep HSC in a quiescent stage.