tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis

Figure 12

Protein expression of CD31 in ischemic quadriceps at day 14 after critical limb ischemia (CLI) induction (). (a) At sham control (SC) treatment condition, CD31 did not differ among four groups, . (b) At CLI subgroup, groups with different symbols (, , , and ), . (c) At SC + tPA treatment condition, CD31 did not differ among four groups, . (d) At CLI + tPA subgroup, groups with different symbols (, , , and ), . All statistical analyses were performed by one-way ANOVA followed by Bonferroni multiple comparison post hoc test. tPA = tissue plasminogen activator. for each group.

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