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Stem Cells International
Volume 2016, Article ID 5417565, 23 pages
Research Article

tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis

1Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
2Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3Department of Anesthesiology, Chang Gung Memorial Hospital and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, Taiwan
4Department of Emergency Medicine, E-Da Hospital, I-Shou University, Kaohsiung 824, Taiwan
5Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 333, Taiwan
6Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
7Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
8Department of Nursing, Asia University, Taichung 413, Taiwan

Received 2 March 2016; Revised 3 June 2016; Accepted 20 June 2016

Academic Editor: Eva Mezey

Copyright © 2016 Steve Leu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental Figure 1: Experimental grouping and design of present study. Upper panel: The schematic illustration of the grouping for the bone marrow cell (BMC) transplantation model. Lower panel: The schematic illustration of experimental grouping and procedures for BMC transplantation, critical limb ischemia (CLI) induction, blood flow observation, and sample collection. MMP-9, matrix metalloproteinase-9; PB, peripheral blood; BM, bone marrow.

  1. Supplementary Material