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Stem Cells International
Volume 2016, Article ID 5638204, 9 pages
http://dx.doi.org/10.1155/2016/5638204
Research Article

Adipose-Derived Stem Cells Alleviate Radiation-Induced Muscular Fibrosis by Suppressing the Expression of TGF-β1

Department of Radiotherapy, The Affiliated Changzhou No. 2 People’s Hospital, Nanjing Medical University, Changzhou 21300, China

Received 28 June 2015; Revised 12 August 2015; Accepted 31 August 2015

Academic Editor: Christian Dani

Copyright © 2016 Wei Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. P. Rodemann and M. Bamberg, “Cellular basis of radiation-induced fibrosis,” Radiotherapy and Oncology, vol. 35, no. 2, pp. 83–90, 1995. View at Publisher · View at Google Scholar · View at Scopus
  2. M. J. Lim, J. Y. Ahn, J. Y. Yi et al., “Induction of galectin-1 by TGF-β1 accelerates fibrosis through enhancing nuclear retention of Smad2,” Experimental Cell Research, vol. 326, no. 1, pp. 125–135, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Terrazzino, P. La Mattina, G. Gambaro et al., “Common variants of GSTP1, GSTA1, and TGFβ1 are associated with the risk of radiation-induced fibrosis in breast cancer patients,” International Journal of Radiation Oncology Biology Physics, vol. 83, no. 2, pp. 504–511, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Yang, J. Palm, J. König et al., “Matrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury,” International Journal of Radiation Biology, vol. 83, no. 10, pp. 665–676, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. L.-C. Hsieh, J. W. Chen, L.-Y. Wang et al., “Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging,” PLoS ONE, vol. 9, no. 3, Article ID e92561, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. P. S. Satheeshkumar, M. P. Mohan, and J. Jacob, “Restricted mouth opening and trismus in oral oncology,” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 117, no. 6, pp. 709–715, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Tedla, M. Valach, R. L. Carrau et al., “Impact of radiotherapy on laryngeal intrinsic muscles,” European Archives of Oto-Rhino-Laryngology, vol. 269, no. 3, pp. 953–958, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. Y.-L. Hsieh, M.-H. Chang, and C.-C. Wang, “Laryngeal electromyography findings of vocal fold immobility in patients after radiotherapy for nasopharyngeal carcinoma,” Head & Neck, vol. 36, no. 6, pp. 867–872, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. M. S. Anscher, “The irreversibility of radiation-induced fibrosis: Fact or folklore?” Journal of Clinical Oncology, vol. 23, no. 34, pp. 8551–8552, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. R. J. Smeenk, A. L. Hoffmann, W. P. M. Hopman, E. N. J. T. van Lin, and J. H. A. M. Kaanders, “Dose-effect relationships for individual pelvic floor muscles and anorectal complaints after prostate radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 83, no. 2, pp. 636–644, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Lindroos, R. Suuronen, and S. Miettinen, “The potential of adipose stem cells in regenerative medicine,” Stem Cell Reviews and Reports, vol. 7, no. 2, pp. 269–291, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. P. A. Zuk, M. Zhu, P. Ashjian et al., “Human adipose tissue is a source of multipotent stem cells,” Molecular Biology of the Cell, vol. 13, no. 12, pp. 4279–4295, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Akita, K. Akino, A. Hirano, A. Ohtsuru, and S. Yamashita, “Noncultured autologous adipose-derived stem cells therapy for chronic radiation injury,” Stem Cells International, vol. 2010, Article ID 532704, 8 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Benderitter, F. Caviggioli, A. Chapel et al., “Stem cell therapies for the treatment of radiation-induced normal tissue side effects,” Antioxidants and Redox Signaling, vol. 21, no. 2, pp. 338–355, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Zhang, S. Zhou, Y. Zhou et al., “Hepatocyte growth factor gene-modified adipose-derived mesenchymal stem cells ameliorate radiation induced liver damage in a rat model,” PLoS ONE, vol. 9, no. 12, Article ID e114670, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. L.-H. Dong, Y.-Y. Jiang, Y.-J. Liu et al., “The anti-fibrotic effects of mesenchymal stem cells on irradiated lungs via stimulating endogenous secretion of HGF and PGE2,” Scientific Reports, vol. 5, article 8713, 2015. View at Publisher · View at Google Scholar
  17. R. Ogawa, H. Mizuno, A. Watanabe, M. Migita, H. Hyakusoku, and T. Shimada, “Adipogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice—including relationship of sex differences,” Biochemical and Biophysical Research Communications, vol. 319, no. 2, pp. 511–517, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Guo, W. Lou, Y. Ji, and S. Zhang, “Effect of CCR7, CXCR4 and VEGF-C on the lymph node metastasis of human pancreatic ductal adenocarcinoma,” Oncology Letters, vol. 5, no. 5, pp. 1572–1578, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Krupinski, P. Kumar, S. Kumar, and J. Kaluza, “Increased expression of TGF-β1 in brain tissue after ischemic stroke in humans,” Stroke, vol. 27, no. 5, pp. 852–857, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. C. C. M. Persons, A. F. Hermens, N. A. P. Franken, and J. Wondergem, “Muscle wasting after radiotherapy in young and adult rats,” Oncology Reports, vol. 8, no. 5, pp. 1117–1122, 2001. View at Publisher · View at Google Scholar
  21. H.-Y. Hsu, C.-Y. Chai, and M.-S. Lee, “Radiation-induced muscle damage in rats after fractionated high-dose irradiation,” Radiation Research, vol. 149, no. 5, pp. 482–486, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Delanian and J.-L. Lefaix, “Current management for late normal tissue injury: radiation-induced fibrosis and necrosis,” Seminars in Radiation Oncology, vol. 17, no. 2, pp. 99–107, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Albersen, M. Kendirci, F. van der Aa, W. J. G. Hellstrom, T. F. Lue, and J. L. Spees, “Multipotent stromal cell therapy for cavernous nerve injury-induced erectile dysfunction,” The Journal of Sexual Medicine, vol. 9, no. 2, pp. 385–403, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Seki, Y. Sakai, T. Komura et al., “Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model,” Hepatology, vol. 58, no. 3, pp. 1133–1142, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Tzouvelekis, V. Paspaliaris, G. Koliakos et al., “A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis,” Journal of Translational Medicine, vol. 11, no. 1, article 171, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Kojima, S.-I. Kanemaru, S. Hirano et al., “Regeneration of radiation damaged salivary glands with adipose-derived stromal cells,” Laryngoscope, vol. 121, no. 9, pp. 1864–1869, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Martin, J.-L. Lefaix, and S. Delanian, “TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?” International Journal of Radiation Oncology Biology Physics, vol. 47, no. 2, pp. 277–290, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Martin, J.-L. Lefaix, P. Pinton, F. Crechet, and F. Daburon, “Temporal modulation of TGF-β1 and β-actin gene expression in pig skin and muscular fibrosis after ionizing radiation,” Radiation Research, vol. 134, no. 1, pp. 63–70, 1993. View at Publisher · View at Google Scholar · View at Scopus
  29. Z.-Z. Shen, J.-J. Zheng, M.-Y. Jia, G. Dong, and T. Li, “Pathological changes of soft tissues and transforming growth factor beta 1 expression in radiation masseter injury models,” Journal of Clinical Rehabilitative Tissue Engineering Research, vol. 15, no. 15, pp. 2842–2846, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. M. S. Anscher, I. R. Crocker, and R. L. Jirtle, “Transforming growth factor-β1 expression in irradiated liver,” Radiation Research, vol. 122, no. 1, pp. 77–85, 1990. View at Publisher · View at Google Scholar · View at Scopus
  31. E. J. Chung, K. Hudak, J. A. Horton et al., “Transforming growth factor alpha is a critical mediator of radiation lung injury,” Radiation Research, vol. 182, no. 3, pp. 350–362, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Li, W. Foster, B. M. Deasy et al., “Transforming growth factor-β1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis,” The American Journal of Pathology, vol. 164, no. 3, pp. 1007–1019, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Burger, H. Löffler, M. Bamberg, and H. P. Rodemann, “Molecular and cellular basis of radiation fibrosis,” International Journal of Radiation Biology, vol. 73, no. 4, pp. 401–408, 1998. View at Publisher · View at Google Scholar · View at Scopus