Bone Anabolic Effects of Soluble Si: In Vitro Studies with Human Mesenchymal Stem Cells and CD14+ Osteoclast Precursors

Figure 5

Modulation of intracellular signalling pathways by Si. Cell cultures were treated with several inhibitors and assessed for ALP activity (hMSC cultures, panel (a)) or TRAP activity (CD14+ cell cultures, panel (b)). Significantly different from the absence of inhibitors. Black arrows represent the main differences observed in Si-treated cultures, compared to the corresponding negative controls (absence of Si).

(a)

(b)