Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2016, Article ID 5687589, 11 pages
http://dx.doi.org/10.1155/2016/5687589
Research Article

A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self-Renewal Capacity and Pluripotency of Human Bone Marrow-Derived Mesenchymal Stem Cells

Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China

Received 19 June 2015; Revised 11 August 2015; Accepted 12 August 2015

Academic Editor: Toru Hosoda

Copyright © 2016 Ni Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Strioga, S. Viswanathan, A. Darinskas, O. Slaby, and J. Michalek, “Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells,” Stem Cells and Development, vol. 21, no. 14, pp. 2724–2752, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Bieback, S. Kern, H. Klüter, and H. Eichler, “Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood,” Stem Cells, vol. 22, no. 4, pp. 625–634, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. H. K. Salem and C. Thiemermann, “Mesenchymal stromal cells: current understanding and clinical status,” Stem Cells, vol. 28, no. 3, pp. 585–596, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Wang, X. Chen, W. Cao, and Y. Shi, “Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications,” Nature Immunology, vol. 15, no. 11, pp. 1009–1016, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. S.-L. Chen, W.-W. Fang, F. Ye et al., “Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction,” American Journal of Cardiology, vol. 94, no. 1, pp. 92–95, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Kharaziha, P. M. Hellström, B. Noorinayer et al., “Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial,” European Journal of Gastroenterology and Hepatology, vol. 21, no. 10, pp. 1199–1205, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. O. Ringdén, M. Uzunel, I. Rasmusson et al., “Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease,” Transplantation, vol. 81, no. 10, pp. 1390–1397, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. V. K. Prasad, K. G. Lucas, G. I. Kleiner et al., “Efficacy and safety of ex vivo cultured adult human mesenchymal stem cells (Prochymal) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate use study,” Biology of Blood and Marrow Transplantation, vol. 17, no. 4, pp. 534–541, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. F. A. Pereira, G. Qiu, M. J. Zhou, and S. Y. Tsai, “The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development,” Genes & Development, vol. 13, no. 8, pp. 1037–1049, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. X. Xie, J. Qin, S.-H. Lin, S. Y. Tsai, and M.-J. Tsai, “Nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) modulates mesenchymal cell commitment and differentiation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 36, pp. 14843–14848, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Li, X. Xie, J. Qin et al., “The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism,” Cell Metabolism, vol. 9, no. 1, pp. 77–87, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. K. W. Orford and D. T. Scadden, “Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation,” Nature Reviews Genetics, vol. 9, no. 2, pp. 115–128, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. S. J. Greco, K. Liu, and P. Rameshwar, “Functional similarities among genes regulated by Oct4 in human mesenchymal and embryonic stem cells,” Stem Cells, vol. 25, no. 12, pp. 3143–3154, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. U. Riekstina, I. Cakstina, V. Parfejevs et al., “Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis,” Stem Cell Reviews and Reports, vol. 5, no. 4, pp. 378–386, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Pierantozzi, B. Gava, I. Manini et al., “Pluripotency regulators in human mesenchymal stem cells: expression of NANOG but not of OCT-4 and SOX-2,” Stem Cells and Development, vol. 20, no. 5, pp. 915–923, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Hu, K. D. Wilson, Z. Ghosh et al., “MicroRNA-302 increases reprogramming efficiency via repression of NR2F2,” Stem Cells, vol. 31, no. 2, pp. 259–268, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. O. V. Leontieva and M. V. Blagosklonny, “CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion,” Cell Cycle, vol. 12, no. 18, pp. 3063–3069, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Qin, S.-P. Wu, C. J. Creighton et al., “COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis,” Nature, vol. 493, no. 7431, pp. 236–240, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. I. Takada, A. P. Kouzmenko, and S. Kato, “Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies,” Expert Opinion on Therapeutic Targets, vol. 13, no. 5, pp. 593–603, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. W.-H. Yu, F.-G. Li, X.-Y. Chen et al., “PPARγ suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cells,” International Journal of Biochemistry and Cell Biology, vol. 44, no. 2, pp. 377–384, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. K.-N. Lee, W.-G. Jang, E.-J. Kim et al., “Orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) protein negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation through suppressing runt-related gene 2 (Runx2) activity,” The Journal of Biological Chemistry, vol. 287, no. 23, pp. 18888–18899, 2012. View at Publisher · View at Google Scholar · View at Scopus