DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation

Table 1

A summary of differential gene expression in DNA methyltransferases and demethylases following MuSC activation (fold change compared to quiescent MuSCs).

	Ryall et al. 2015 [18]; (RNAseq, in vitro MuSC activation)	Pallafacchina et al. 2010 [19]; (microarray, in vitro MuSC activation)	Liu et al. 2013 [20]; (microarray, in vivo MuSC activation)	Pallafacchina et al. 2010 [19]; (microarray, MuSCs from one-week-old mice)	Pallafacchina et al. 2010 [19]; (microarray, MuSCs from mdx dystrophic mice)
Dnmt1	↑ 4-fold	↑ 6-fold	↑ 6-fold	↑ 7-fold	↑ 3-fold
Dnmt3a	↓ 3-fold	↓ 3-fold	NA	↑ 3-fold	↔
Dnmt3b	↔	NA	NA	NA	NA
Tet1	↓ 10-fold	NA	↓ 5-fold	NA	NA
Tet2	↓ 2-fold	↓ 13-fold	↓ 3-fold	NA	NA
Tet3	↓ 2-fold	NA	NA	NA	NA

DNMT: DNA methyltransferase; Tet: ten-eleven translocase; MuSC: muscle stem cell; NA: not available.