Review Article
Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
Table 1
Currently defined HSC subsets in mouse and their definition by mature cell output and cell surface markers.
| | HSC subset | Predominant mature cell population | Cell surface markers that have been used for prospective identification |
| | Mouse HSC | | Lin− Sca-1+ cKit+ CD150+ CD48− CD34− | | Myeloid-biased/lymphoid-deficient (α) | Myeloid | +CD150High, CD41+ | | Lymphoid-biased/myeloid-deficient (γ/δ) | Lymphoid | +CD229+ | | Balanced (β) | Myeloid and lymphoid | | | Platelet-biased | Platelet and myeloid | +VWF+, CD41+ | | Human HSC | | Lin− CD34+ CD38− CD90+ CD45RA− CD49f+ |
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Lin: lineage markers; VWF: von Willebrand factor.
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