Synovial Sarcoma Microvesicles Harbor the SYT-SSX Fusion Gene Transcript: Comparison of Different Methods of Detection and Implications in Biomarker Research

Figure 3

Nanoparticle Tracking Analysis (NTA) of microvesicles purified from serum of patients with active synovial sarcoma ((a)–(c)) and synovial sarcoma cells ((d)–(f)). Mean diameter peaks were 151.7 nm for microvesicles extracted from synovial sarcoma patient serum ((a)–(c)) and 154.4 nm ((d)–(f)) for microvesicles purified from synovial sarcoma cells. Mean concentration levels were 3155.0 × 10⁹ particles/mL in serum of patients with active synovial sarcoma ((a)–(c)) and 18.60 × 10⁹ particles/mL in synovial sarcoma cell supernatant ((d)–(f)).

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