BMP6-Engineered MSCs Induce Vertebral Bone Repair in a Pig Model: A Pilot Study

Figure 1

Vertebral bone defect: surgical procedure. Cylindrical bone defects were generated in the lumbar vertebrae of minipigs and treated with either BMP6-MSCs or fibrin gel only. A surgical drill was used to perform the defect in the lumbar vertebral body (a). A 4 mm in diameter, 15-mm deep, cylindrical defect was generated and prepared for construct implantation (b). BMP6-MSCs suspended in fibrin gel or fibrin gel only (control) constructs were implanted in the defect site (c). White arrows point to the location of the defect.

(a)

(b)

(c)