Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma

Table 2

Cox proportional hazard regression model of factors prognostic of overall survival in patients with pGBM.

Characteristics	Univariate			Multivariate
	OR	95% CI	value	OR	95% CI	value
Isolation of tMSLCs	2.4	1.2~5.1	0.017	2.5	1.1~5.6	0.021
Age ≥ 50 years	1.3	0.5~3.1	0.587
Extent of resection	0.7	0.4~1.1	0.151	0.5	0.2~0.8	0.011
IDH1 mutation	1.6	0.4~6.7	0.551
LOH 1p19q	1.3	0.6~3.0	0.532	1.1	0.4~2.6	0.869
MGMT methylation	0.8	0.4~1.6	0.522	0.9	0.4~1.9	0.792
p53 ≥ 50%	0.7	0.2~1.8	0.418
EGFR	1.1	0.7~1.5	0.782
Ki 67 index ≥ 10%	3.3	0.5~24.7	0.235	5.4	0.7~42.0	0.107

tMSLCs: tumor mesenchymal stem-like cells; IDH: isocitrate dehydrogenase; LOH: loss of heterozygosity; MGMT: O-6-methylguanine-DNA methyltransferase; EGFR: epidermal growth factor receptor; OR: odds ratio; CI: confidence interval.