TY - JOUR
A2 - Zhang, Su-Chun
AU - Klingenstein, Moritz
AU - Raab, Stefanie
AU - Achberger, Kevin
AU - Kleger, Alexander
AU - Liebau, Stefan
AU - Linta, Leonhard
PY - 2016
DA - 2015/11/30
TI - TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells
SP - 6759343
VL - 2016
AB - TBX3 is a member of the T-box transcription factor family and is involved in the core pluripotency network. Despite this role in the pluripotency network, its contribution to the reprogramming process during the generation of human induced pluripotent stem cells remains elusive. In this respect, we performed reprogramming experiments applying TBX3 knockdown in human fibroblasts and keratinocytes. Knockdown of TBX3 in both somatic cell types decreased the reprogramming efficiencies in comparison to control cells but with unchanged reprogramming kinetics. The resulting iPSCs were indistinguishable from control cells and displayed a normal in vitro differentiation capacity by generating cells of all three germ layers comparable to the controls.
SN - 1687-966X
UR - https://doi.org/10.1155/2016/6759343
DO - 10.1155/2016/6759343
JF - Stem Cells International
PB - Hindawi Publishing Corporation
KW -
ER -