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Category | Engineered version | Modification(s) | Reference(s) |
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BMP2-based | B2A (B2A2-K-NS) | BMP2-based peptide with heparin-binding domain that augments activity of BMP2 but has no signaling ability alone | [54–59, 151] |
BMP2-L51P | BMP2 mutant that augments activity of BMP2 but has no signaling ability alone | [51–53] |
BMP2_108 | BMP2-based peptide; mimics activity of BMP2 | [20] |
mBMP | BMP2-based peptide with mineral-binding domain; mimics activity of BMP2 | [21] |
OPD | BMP2-based peptide; mimics or presumed to mimic activity of BMP2 | [22] |
P1 | BMP2-based peptide; mimics or presumed to mimic activity of BMP2 | [23] |
P2 | BMP2-based peptide; mimics or presumed to mimic activity of BMP2 |
P24 | BMP2-based peptide; mimics or presumed to mimic activity of BMP2 | [24, 25] |
PEP7 | BMP2-based peptide; mimics or presumed to mimic activity of BMP2 | [26] |
Unnamed | BMP2-based peptide; mimics or presumed to mimic activity of BMP2 | [27–34] |
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BMP2/Activin A chimerae | AB204 | Segmental-chimera of BMP2 and Activin A with enhanced activity over BMP2; Noggin resistant | [35, 42–46] |
AB204-I103Y | Variant of AB204; enhanced activity over BMP2 and AB204 | [42] |
AB211 | Segmental-chimera of BMP2 and Activin A with enhanced activity over BMP2; Noggin resistant | [35] |
AB215 | Segmental-chimera of BMP2 and Activin A with enhanced activity over BMP2; Noggin resistant | [35, 47] |
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BMP2/BMP9 chimera | BB29 | Segmental-chimera of BMP2 and BMP9 with enhanced folding when produced in E. coli | [35] |
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BMP6/BMP7 chimera | 80-1 | Segmental-chimera of BMP6 and BMP7 with reduced Noggin binding when compared to BMP7 | [48] |
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BMP7-based | BMP7-E60K | BMP6-informed mutant with reduced Noggin binding | [48] |
THR-123 | BMP7-based peptide | [36] |
Unnamed | BMP7-based peptide; mimics activity of BMP7 | [27] |
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BMP9-based | MB109 | BMP9-based peptide optimized for production in E. coli | [37] |
pBMP9 | BMP9-based peptide with enhanced activity over BMP9 | [38–40] |
SpBMP9 | BMP9-based peptide with enhanced activity over BMP9 | [40] |
Unnamed | BMP9-based peptide; mimics activity of BMP9 | [27] |
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GDF5-based | GDF5-S94N | Naturally-occurring mutant with enhanced activity due to decreased inhibition by Noggin | [48] |
GDF5-N445K | Naturally-occurring mutant with enhanced activity due to decreased inhibition by Noggin | [49] |
GDF5-N445T | Naturally-occurring mutant with enhanced activity due to decreased inhibition by Noggin | [49, 50] |
GDF5-V453/V456 | BMP2-informed variant of GDF5; enhanced activity over GDF5 and BMP2 | [152, 153] |
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Heterodimers | BMP2/6 | Heterodimer with enhanced activity over BMP2 and BMP6 | [60, 61] |
BMP2/7 | Heterodimer with enhanced activity over BMP2 and BMP7 | [62–67] |
BMP4/7 | Heterodimer with enhanced activity over BMP4 and BMP7 | [68–70] |
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