Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

Figure 1

Skin aging induced by UVR-induced DNA damage to ESCs. UVR is the major skin stressor capable of damaging ESC DNA (UV-B) or promoting production of the DNA toxic ROS (UV-A). DNA damaging effects of UVR result in activation of cell cycle arrest (checkpoint activation) and DNA repair proteins, damaged stem cell niche, and dermal fibroblasts. These facilitate ESC depletion and loss of extracellular matrix (ECM) integrity, leading to premature skin aging.