Stem Cells International / 2016 / Article / Tab 1

Research Article

Implant Composed of Demineralized Bone and Mesenchymal Stem Cells Genetically Modified with AdBMP2/AdBMP7 for the Regeneration of Bone Fractures in Ovis aries

Table 1

Toxicity studies related to the use of adenoviral vectors.

Analytical parameterReference rangeGroup IGroup IIGroup III
Pre SPost SPre SPost SPre SPost S

Leukocytes (μL)4000–120005507.5 ± 0.311086 ± 0.39748.3 ± 0.38375 ± 0.211251.7 ± 0.58758.3 ± 0.3
Hemoglobin (g/dL)9–1511.9 ± 0.29.72 ± 0.110.2 ± 0.210.3 ± 0.110.7 ± 0.110.1 ± 0.1
Platelets (thousands/μL)220–680376.2 ± 0.5832.2 ± 0.3470.3 ± 0.2779.3 ± 0.4684.1 ± 0.4720.8 ± 0.5
PT (g/dL)6.0–7.96.36 ± 0.16.68 ± 0.16.1 ± 0.07.1 ± 0.16.8 ± 0.16.8 ± 0.1
Albumin (g/dL)2.4–3.03.46 ± 0.12.9 ± 0.13.1 ± 0.13.1 ± 0.13.1 ± 0.13.2 ± 0.1
Globulin (g/dL)3.5–5.72.86 ± 0.13.76 ± 0.23.05 ± 0.14.2 ± 0.33.7 ± 0.23.5 ± 0.2
AST (IU/L)66–194146.4 ± 0.4174.6 ± 0.3131.5 ± 0.3140.3 ± 0.6112.1 ± 0.1104.3 ± 0.2
ALT (IU/L)12–3717.8 ± 0.327 ± 0.919 ± 0.516.7 ± 0.315 ± 0.616.5 ± 0.4
Total bilirubin (mg/dL)0.0–1.00.108 ± 0.40.032 ± 0.40.1 ± 0.60.04 ± 1.10.06 ± 0.60.04 ± 0.8
Total bilirubin (mg/dL)0.0–0.20.03 ± 0.20.03 ± 0.40.1 ± 0.80.1 ± 1.20.04 ± 1.00.1 ± 0.7
Indirect bilirubin (mg/dL)0.0–1.00.076 ± 0.60.03 ± 0.40.1 ± 0.80.1 ± 1.20.04 ± 1.00.1 ± 0.7
Alkaline phosphatase (IU/L)68–387305.8 ± 0.5134.4 ± 0.2167.5 ± 0.6188.5 ± 0.3198 ± 0.4211.3 ± 0.3
GGT (IU/L)36–10253.8 ± 0.251.8 ± 0.168.2 ± 0.373.7 ± 0.349.07 ± 0.258.0 ± 0.4

Pre S: presurgery; Post S: postsurgery.

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