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Stem Cells International
Volume 2016 (2016), Article ID 7614971, 14 pages
http://dx.doi.org/10.1155/2016/7614971
Review Article

The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma

1Department of Infectious Disease, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China
2Department of Nursing, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China

Received 22 March 2016; Revised 6 June 2016; Accepted 4 July 2016

Academic Editor: Michaela Reagan

Copyright © 2016 Yan Xiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Accumulating evidence suggests that hepatocellular carcinoma (HCC) is organized by liver cancer stem cells (LCSCs), which are a subset of cells with “stem-like” characteristics. Identification of the LCSCs is a fundamental and important problem in HCC research. LCSCs have been investigated by various stem cell biomarkers. There is still lack of consensus regarding the existence of a “global” marker for LCSCs in HCC. In this review article, we summarize the progress and prospects of putative biomarkers for LCSCs in the past decades, which is essential to develop future therapies targeting CSCs and to predict prognosis and curative effect of these therapies.