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Stem Cells International
Volume 2016, Article ID 8102478, 11 pages
Research Article

Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer’s Disease Treatment: An In Vitro Study

1Department of Stem Cell Biology and Regenerative Medicine, National Center for Geriatrics and Gerontology, Research Institute, Obu, Aichi 474-8511, Japan
2Department of Orodental Genetics, Division of Human Genetics and Human Genome, National Research Center, Cairo 12311, Egypt
3Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan

Received 14 December 2015; Revised 25 April 2016; Accepted 16 May 2016

Academic Editor: Pavla Jendelova

Copyright © 2016 Nermeen El-Moataz Bellah Ahmed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1: Donor information for used dental pulp derived mesenchymal stem cells.

Supplementary Table 2: Donor information for used bone marrow-derived mesenchymal stem cells.

Supplementary Table 3: Donor information for used Adipose-derived mesenchymal stem cells.

Supplementary Figure 1: DPSC secretome treatment preserves morphology and improves viability of SH-SY5Y cells exposed to Aβ1–42.

Supplementary Figure 2: DPSC secretome stimulates the endogenous survival factor Bcl-2 and decreases the apoptotic regulator Bax.

Supplementary Figure 3: DPSC secretome contains higher concentration of Neprilysin/CD10.

Supplementary Figure 4: DPSC secretome degrade Aβ1–42 protein in vitro.

Supplementary Figure 5: DPSC secretome has neuroprotective ability against Aβ1–42 induced neurotoxicity.

  1. Supplementary Material