Research Article

Induction of Functional Hair-Cell-Like Cells from Mouse Cochlear Multipotent Cells

Figure 5

The surface of differentiated cells observed by scanning electron microscopy. (a) The surface of the cochlear multipotent cells had no stereocilia. ((b) and (c)) Cells differentiated on poly-L-lysine (as shown in Figure 2(a)) with some hair-cell-like cells displaying disorganized stereocilia. (d) Cells differentiated on the mitotically inactivated chicken utricle stromal cells (as shown in Figure 2(a)) showed hair bundle-like structures. (e) The stereocilia of the hair-cell-like cells were tapered at their bases (arrowhead in (e)). (f) Many interstereocilia links existed among the tips of stereocilia (arrowhead in (f)).