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Stem Cells International
Volume 2016, Article ID 8270464, 11 pages
http://dx.doi.org/10.1155/2016/8270464
Research Article

In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage

1Alexander B. Osborn Hematopoietic Malignancy and Transplantation Program of the West Virginia University Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, WV 26506, USA
2Department of Microbiology, Immunology and Cell Biology, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, WV 26506, USA
3Department of Pathology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA

Received 11 August 2015; Revised 22 November 2015; Accepted 25 November 2015

Academic Editor: Silvia Brunelli

Copyright © 2016 Ian Hare et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Ian Hare, Rebecca Evans, James Fortney, Blake Moses, Debbie Piktel, William Slone, and Laura F. Gibson, “Chemotherapy-induced Dkk-1 expression by primary human mesenchymal stem cells is p53 dependent,” Medical Oncology, vol. 33, no. 10, 2016. View at Publisher · View at Google Scholar
  • Lewis Reynolds, “The success of stem cell transplantations and the potential post-transplantation complications may be dependent, among other factors, on the capacity of the recipient and the transplanted cells to repair DNA damage,” BioDiscovery, vol. 19, pp. e9076, 2016. View at Publisher · View at Google Scholar
  • Rumena Petkova, Nikolai Zhelev, Roumen Pankov, and Stoyan Chakarov, “Individual capacity for repair of DNA damage and potential uses of stem cell lines for clinical applications: a matter of (genomic) integrity,” Biotechnology & Biotechnological Equipment, pp. 1–7, 2018. View at Publisher · View at Google Scholar
  • Hang Lin, He Shen, and Rocky S. Tuan, “Aging of Human Mesenchymal Stem Cells,” Conn's Handbook of Models for Human Aging, pp. 975–994, 2018. View at Publisher · View at Google Scholar
  • Timo Z. Nazari-Shafti, Zhiyi Xu, Andreas Matthäus Bader, Georg Henke, Kristin Klose, Volkmar Falk, and Christof Stamm, “Mesenchymal Stromal Cells Cultured in Serum from Heart Failure Patients Are More Resistant to Simulated Chronic and Acute Stress,” Stem Cells International, vol. 2018, pp. 1–15, 2018. View at Publisher · View at Google Scholar
  • Taylor McNeely, Michael Leone, Hagai Yanai, and Isabel Beerman, “DNA damage in aging, the stem cell perspective,” Human Genetics, 2019. View at Publisher · View at Google Scholar