Comparison of Osteogenesis between Adipose-Derived Mesenchymal Stem Cells and Their Sheets on Poly--Caprolactone/-Tricalcium Phosphate Composite Scaffolds in Canine Bone Defects

Figure 5

Expression of osteogenic differentiation markers. The expression of RUNX2, ALP, osteopontin, BMP7, and TGF- mRNA was significantly upregulated in O-MSCs and OCS (). RUNX2 and TGF- transcript levels were higher in OCS than in the O-MSCs group (). AXIN2 and -catenin mRNA expression was upregulated in O-MSCs and OCS (). : compared to the U-MSCs group, : compared to the O-MSCs group.