Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HA/Collagen/PLA Scaffold

Figure 6

Bone regeneration in a rabbit critical-size mandibular defect model stained with Goldner’s trichrome. (a) The defects in the nHAC/PLA group were filled with abundant red-stained osteoid tissue and some green-stained newly formed bone. (b) The defects in the nHAC/PLA + aBMSCs group were filled with more newly formed trabeculae. (c) The defects in the nHAC/PLA + preinduced aBMSCs group were filled with a large amount of mature thickened bone. (d) The AB group exhibited areas of newly formed bone, osteoid tissue, osteoblastic seams, and residual bone graft. Magnification: ×400. NB: new mature bone; AB: autogenous bone; OS: osteoid tissue.

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