The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative Medicine

Table 1

Genes associated with both ALS and FTD.

Gene	Locus	Protein	Putative function	Reference
CHMP2B	3p11	Charged multivesicular body protein 2B	Vesicle trafficking	[44]
TARDBP	1p36	TAR DNA binding protein 43	RNA metabolism	[39, 45, 46]
VCP	9p13	Valosine; -containing protein	Ubiquitination; proteasomal degradation	[47]
UBQLN2	Xp11	Ubiquilin 2	Ubiquitination; proteasomal degradation	[48]
C9ORF72	9p21	Chromosome 9 open reading frame 72	Intracellular trafficking; RNA metabolism	[49, 50]
TUBA4A	2q35	Tubulin, alpha 4A protein	Cytoskeleton dynamics	[51]