Effects of Serial Passage on the Characteristics and Cardiac and Neural Differentiation of Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells
Chromosome analysis and the expression of oncogenes, E-Ras and c-Myc, in WJ MSCs (Wharton’s jelly-derived mesenchymal stem cells) in the early, middle, and late phases. (a–c) Chromosome analysis indicated that serial passage did not change the number of chromosome in WJ MSCs regardless of the phases. (d) There were no significant differences in E-Ras gene expression among different phases. (e) The c-Myc gene expression in WJ MSCs in the late phase was upregulated, remarkably higher than the early phase and the middle phase ().
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