Research Article

Characterization of Cellular and Molecular Heterogeneity of Bone Marrow Stromal Cells

Table 1

Microarray data analysis showing genes related to bone development and osteoblast differentiation upregulated in CL1 versus CL2 cells.

Probe IDGenbank accessionGene nameGene symbolFC

A_23_P167367NM_153426Paired-like homeodomain 2PITX2308.84
A_23_P13907NM_000618Insulin-like growth factor 1 (somatomedin C)IGF1118.00
A_23_P55749NM_015719Collagen, type V, alpha 3COL5A375.11
A_23_P94397NM_005014OsteomodulinOMD56.07
A_24_P128442NM_152380T-box 15TBX1554.38
A_33_P3708413NM_003480Microfibrillar associated protein 5MFAP553.73
A_24_P72064NM_000163Growth hormone receptorGHR51.47
A_23_P215454NM_001278939ElastinELN50.15
A_24_P200854NM_006735Homeobox A2HOXA244.99
A_23_P19624NM_001718Bone morphogenetic protein 6BMP641.43
A_23_P500501NM_000142Fibroblast growth factor receptor 3FGFR333.95
A_23_P154605NM_018837Sulfatase 2SULF229.57
A_23_P28815NM_000782Cytochrome P450, family 24, subfamily A, polypeptide 1CYP24A122.47
A_23_P210109NM_019885Cytochrome P450, family 26, subfamily B, polypeptide 1CYP26B122.42
A_23_P323180NM_006898Homeobox D3HOXD321.08
A_32_P405759NM_152888Collagen, type XXII, alpha 1COL22A120.36
A_33_P3363799NM_001242607Neural cell adhesion molecule 1NCAM117.33
A_33_P3381378NM_001257096Paired box 1PAX117.12
A_23_P383009NM_000599Insulin-like growth factor binding protein 5IGFBP514.67
A_33_P3382856NM_133507DecorinDCN14.38
A_23_P10206NM_005328Hyaluronan synthase 2HAS214.33
A_24_P77904NM_018951Homeobox A10HOXA1013.64
A_23_P2814NM_005905SMAD family member 9SMAD912.45
A_23_P88404NM_003239Transforming growth factor, beta 3TGFB312.11
A_32_P4595NM_000337Sarcoglycan, delta (35 kDa dystrophin-associated glycoprotein)SGCD8.95
A_23_P162171NM_006500Melanoma cell adhesion moleculeMCAM8.60
A_24_P38276NM_003505Frizzled class receptor 1FZD17.81
A_23_P24129NM_012242Dickkopf WNT signaling pathway inhibitor 1DKK17.04
A_33_P3264528NM_005523Homeobox A11HOXA116.64
A_33_P3220470NM_005585SMAD family member 6SMAD66.47
A_23_P23783NM_000261Myocilin, trabecular meshwork inducible glucocorticoid responseMYOC6.41
A_33_P3263432NM_003637Integrin, alpha 10ITGA106.35
A_23_P383009NM_000599Insulin-like growth factor binding protein 5IGFBP56.18
A_33_P3219090NM_005542Insulin induced gene 1INSIG15.78
A_23_P162589NM_001017535Vitamin D (1,25-dihydroxyvitamin D3) receptorVDR5.68
A_23_P374695NM_000459TEK tyrosine kinase, endothelialTEK5.65
A_24_P261169NM_006378Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM), and short cytoplasmic domain, (semaphorin) 4DSEMA4D5.41
A_33_P3297930NM_005202Collagen, type VIII, alpha 2COL8A25.138
A_23_P206359NM_004360Cadherin 1, type 1, E-cadherin (epithelial)CDH15.12
A_24_P264943NM_000095Cartilage oligomeric matrix proteinCOMP5.07
A_33_P3214948NM_014767Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan (testican) 2SPOCK24.54
A_24_P55496NM_053001Odd-skipped related transcription factor 2OSR24.38
A_24_P354689NM_004598Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan (testican) 1SPOCK14.23
A_23_P69030NM_001850Collagen, type VIII, alpha 1COL8A13.93
A_23_P128084NM_002206Integrin, alpha 7ITGA73.91
A_24_P3249NM_000965Retinoic acid receptor, betaRARB3.91
A_24_P168574AJ224867GNAS complex locusGNAS3.83
A_23_P320739NM_002397Myocyte enhancer factor 2CMEF2C3.74
A_23_P429383NM_014213Homeobox D9HOXD93.54
A_23_P42322NM_080680Collagen, type XI, alpha 2COL11A23.42
A_23_P160318NM_001856Collagen, type XVI, alpha 1COL16A13.36
A_33_P3407013NM_000600Interleukin 6IL63.30
A_23_P315364NM_002089Chemokine (C-X-C motif) ligand 2CXCL23.29
A_33_P3413168BC007696Collagen, type XXVII, alpha 1COL27A13.08
A_23_P43164NM_015170Sulfatase 1SULF13.05
A_23_P58676NM_001204375Natriuretic peptide receptor 3NPR33.04
A_33_P3290562NM_000168GLI family zinc finger 3GLI33.00
A_23_P69497NM_003278C-type lectin domain family 3, member BCLEC3B2.99
A_24_P353619NM_000478Alkaline phosphatase, liver/bone/kidneyALPL2.99
A_33_P3305749NM_000965Retinoic acid receptor, betaRARB2.89
A_23_P307328NM_007331Wolf-Hirschhorn syndrome candidate 1WHSC12.77
A_23_P152305NM_001797Cadherin 11, type 2, OB-cadherin (osteoblast)CDH112.77
A_23_P216361NM_021110Collagen, type XIV, alpha 1COL14A12.62
A_23_P7313NM_001040058Secreted phosphoprotein 1SPP12.60
A_24_P267592NM_015474SAM domain and HD domain 1SAMHD12.54
A_23_P210482NM_000022Adenosine deaminaseADA2.52
A_23_P148047NM_000958Prostaglandin E receptor 4 (subtype EP4)PTGER42.51
A_23_P345725NM_014621Homeobox D4HOXD42.47
A_24_P125283NM_001015053Histone deacetylase 5HDAC52.37
A_33_P3231953NM_004370Collagen, type XII, alpha 1COL12A12.34
A_24_P298027NM_004655Axin 2AXIN22.31
A_24_P336551NM_199173Bone gamma-carboxyglutamate (gla) proteinBGLAP2.29
A_33_P3313825XM_006713316Transforming growth factor, beta receptor II (70/80 kDa)TGFBR22.23
A_23_P82990NM_033014OsteoglycinOGN2.20
A_32_P24585NM_001017995SH3 and PX domains 2BSH3PXD2B2.20
A_24_P944458NM_016133Insulin induced gene 2INSIG22.14
A_23_P99063NM_002345LumicanLUM2.12
A_32_P5251NM_001024809Retinoic acid receptor, alphaRARA2.11
A_24_P935491NM_000090Collagen, type III, alpha 1COL3A12.10
A_33_P3312104NM_025099CTS telomere maintenance complex component 1CTC12.06
A_33_P3321342NM_016133Insulin induced gene 2INSIG22.04
A_23_P100486NM_206824Vitamin K epoxide reductase complex, subunit 1VKORC12.02
A_23_P53588NM_030775Wingless-type MMTV integration site family, member 5BWNT5B2.00
A_23_P616356NM_001291902Low density lipoprotein receptor-related protein 5 LRP52.00