Research Article

Characterization of Cellular and Molecular Heterogeneity of Bone Marrow Stromal Cells

Table 4

Microarray data analysis showing genes found to be upregulated during adipogenic differentiation and downregulated after ALP KO.

62 common elements in “AD up” and “ALP down”Gene nameFC (ALP siRNA versus control siRNA)

APOBEC3GApolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G−15.938025
IFI44LInterferon-induced protein 44-like−11.520283
PAQR5Progestin and adipoQ receptor family member V−6.868241
PNMA2Paraneoplastic antigen MA2−5.9695344
DUSP23Dual specificity phosphatase 23−5.4786854
CLDN23Claudin 23−5.1885047
ANKDD1AAnkyrin repeat and death domain containing 1A−5.1646647
IL8Interleukin 8−4.887188
LRRC23Leucine rich repeat containing 23−4.7611775
IL6Interleukin 6 (interferon, beta 2)−4.693139
LIFRLeukemia inhibitory factor receptor alpha−4.6540866
PTGFRProstaglandin F receptor (FP)−4.457529
FAM134BFamily with sequence similarity 134, member B−4.403495
CYFIP2Cytoplasmic FMR1 interacting protein 2−4.260462
METTL7AMethyltransferase-like 7A−4.0480843
APOBEC3FApolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F−3.9502614
CA5BCarbonic anhydrase VB, mitochondrial−3.93889
ITGA10Integrin, alpha 10−3.9143775
FMO3Flavin containing monooxygenase 3−3.852087
IMPA2Inositol monophosphatase 2 (human)−3.8374884
CDO1Cysteine dioxygenase, type I−3.8181455
CCDC68Coiled-coil domain containing 68−3.7292893
CXCL1Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)−3.5942702
IDO1Indoleamine 2,3-dioxygenase 1−3.5803545
KCNIP3Kv channel interacting protein 3, calsenilin−3.5442894
FADS1Fatty acid desaturase 1−3.2951858
LSRLipolysis stimulated lipoprotein receptor−3.2215986
ITGA7Integrin, alpha 7−3.1355932
HLA-DMAMajor histocompatibility complex, class II, DM alpha−3.1347752
APOBEC3BApolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B−3.1074922
BMP4Bone morphogenetic protein 4−3.0809238
DMBT1Deleted in malignant brain tumors 1−3.0760298
RDH5Retinol dehydrogenase 5 (11-cis/9-cis)−3.066812
EPAS1Endothelial PAS domain protein 1−3.0615559
CDKN3Cyclin-dependent kinase inhibitor 3−3.052319
GPC6Glypican 6−3.0460389
CDK4Cyclin-dependent kinase 4−2.9808035
FKBP5FK506 binding protein 5−2.9360793
PDE1BPhosphodiesterase 1B, calmodulin-dependent−2.8863106
JAM2Junctional adhesion molecule 2−2.884354
TFPITissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)−2.8578906
NT5M5′,3′-Nucleotidase, mitochondrial−2.7555947
NFIANuclear factor I/A−2.7176137
TSPAN31Tetraspanin 31−2.627556
ZNF25Zinc finger protein 25−2.6183622
SULF2Sulfatase 2−2.5464642
MESP1Mesoderm posterior 1 homolog (mouse)−2.525513
BCL2L1BCL2-like 1−2.5119667
PLTPPhospholipid transfer protein−2.4767148
TIMP4TIMP metallopeptidase inhibitor 4−2.465897
CYP27A1Cytochrome P450, family 27, subfamily A, polypeptide 1−2.4572072
TTC39BTetratricopeptide repeat domain 39B−2.4439611
IL1R2Interleukin 1 receptor, type II−2.427431
FMODFibromodulin−2.4185398
LDLRAD3Low density lipoprotein receptor class A domain containing 3−2.4032724
PISDPhosphatidylserine decarboxylase−2.3884957
TMEM100Transmembrane protein 100−2.384632
CHST2Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2−2.3805838
APOBEC3FApolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F−2.3759322
SCDStearoyl-CoA desaturase (delta-9-desaturase)−2.3524246
SPAG4Sperm associated antigen 4−2.280867
MMDMonocyte to macrophage differentiation associated human−2.2055967
ASS1Argininosuccinate synthase 1−2.1725202
GK5Glycerol kinase 5 (putative)−2.1667244
PDE7BPhosphodiesterase 7B−2.166515
MT1XMetallothionein 1X−2.161843
ACACBAcetyl-CoA carboxylase beta−2.1512873
LEPRLeptin receptor−2.148686
HIF1AHypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)−2.0954225
HEXDCHexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing−2.094836
SARM1Sterile alpha and TIR motif containing 1−2.0797038
BBS1Bardet-Biedl syndrome 1−2.0146718
SERPING1Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1−2.0102212
FAM162AFamily with sequence similarity 162, member A−2.005807
TCTN1Tectonic family member 1−2.0033443