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Stem Cells International
Volume 2016, Article ID 9475981, 14 pages
http://dx.doi.org/10.1155/2016/9475981
Research Article

HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

1Department of Microbiology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea
2Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Seoul, Republic of Korea
3Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea
4Chong Kun Dang Research Institute, Yongin-si, Gyeonggi-do, Republic of Korea
5Division of Intractable Diseases, Center for Biomedical Sciences, National Institute of Health, Chungcheongbuk-do, Republic of Korea
6Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, Republic of Korea
7Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

Received 18 July 2016; Revised 11 November 2016; Accepted 22 November 2016

Academic Editor: Yang D. Teng

Copyright © 2016 Ji-Yon Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Material contains PCR detection of Sendai viral genome in iPSCs, and neuromuscular junction staining. It also contains mitochondrial movement data of different two clones from the patients. For comparison, immunostaining of acetylated alpha-tubulin data in S135F-MNs and P182L-MNs with HDAC6 inhibitors are included.

  1. Supplementary Material