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Stem Cells International
Volume 2016, Article ID 9671732, 10 pages
http://dx.doi.org/10.1155/2016/9671732
Research Article

Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells

1Department of Rehabilitation Medicine, The 2nd Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
2Physical Examination Center, Chongqing General Hospital, Chongqing, China
3The 3rd Department of Research Institute of Surgery, Daping Hospital, The Third Military Medical University, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, China
4Kuanren Rehabilitation Hospital, The 2nd Affiliated Hospital of Chongqing Medical University, Chongqing, China

Received 7 May 2016; Revised 31 August 2016; Accepted 20 September 2016

Academic Editor: Laura Lasagni

Copyright © 2016 Botao Tan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Insufficient proliferation, differentiation, and migration are the main pitfalls of neural stem cells (NSCs) in reparative therapeutics for the central nervous system (CNS) diseases. The potent lipid mediator sphingosine-1-phosphate (S1P) regulates cells’ biological behavior broadly in the CNS. However, the effects of activating S1P on NSCs are not quite clear. In the current study, FTY720 (Fingolimod), an analog of S1P, was employed to induce the proliferation, differentiation, and migration of cultured brain-derived NSCs. The results indicated that proliferation and migration ability of NSCs were promoted by FTY720. Though we observed no obvious neuron prefers differentiation of NSCs, there were more protoplasmic astrocytes developed in the presence of certain concentration of FTY720. This work gives more comprehensive understanding of how FTY720 affects NSCs.