Research Article

Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury

Table 1

Functional classification of the highly secreted protein identified in MSC-CdM.

GO classificationGeneProtein

ADP catabolic processNUDT9ADP-ribose pyrophosphatase, mitochondrial

Apoptotic processHINT1Histidine triad nucleotide-binding protein 1
NME1Nucleoside diphosphate kinase A
NME2Nucleoside diphosphate kinase B

Biological processOAFOut at first protein homolog

Biosynthetic processHRT1Hypoxanthine-guanine phosphoribosyltransferase
ADAAdenosine deaminase
EEF1A1Elongation factor 1-alpha 1
TPI1Triosephosphate isomerase
PGAM1Phosphoglycerate mutase 1
EIF2S3XEukaryotic translation initiation factor 2 subunit 3, X-linked

Catabolic processGSTO1Glutathione S-transferase omega-1

Cell adhesionSPP1Osteopontin

Cell cyclePIN4Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

Cell differentiationTPT1Translationally controlled tumor protein
STMN1Stathmin

Cell growthMTPNMyotrophin

Cell morphogenesisSMARCA4Transcription activator BRG1

Cell motilityBRK1Protein BRICK1

Cell-cell signalingHDGFHepatoma-derived growth factor

Cellular component morphogenesisCFL1Cofilin-1
TUBA4ATubulin alpha-4A chain
SAA3Serum amyloid A-3 protein

Cellular processSOD3Extracellular superoxide dismutase [Cu-Zn]
LCN2Neutrophil gelatinase-associated lipocalin
NAMPTNicotinamide phosphoribosyltransferase
UCHL3Ubiquitin carboxyl-terminal hydrolase isozyme L3

DNA replicationPCNAProliferating cell nuclear antigen

Endothelial cell proliferationHMGB1High mobility group protein B1

Fatty acid catabolic processACOT7Cytosolic acyl coenzyme A thioester hydrolase

GlycolysisLDHAL-lactate dehydrogenase A chain
PGK1Phosphoglycerate kinase 1
GAPDHGlyceraldehyde-3-phosphate dehydrogenase
ENO1Alpha-enolase

G-protein coupled receptor signaling pathwayCXCL5C-X-C motif chemokine 5
CCL8C-C motif chemokine 8

Immune system processHMGB2High mobility group protein B2
MIFMacrophage migration inhibitory factor
PSMA1Proteasome subunit alpha type-1

Metabolic processPKMPyruvate kinase PKM

Monosaccharide metabolic processGALMAldose 1-epimerase

Oxidation-reduction processAKR1B1Aldose reductase
AKR1B8Aldose reductase-related protein 2

Pentose phosphate shuntPGLS6-phosphogluconolactonase

Protein foldingHSP90AA1Heat shock protein HSP 90-alpha
HSP90AB1Heat shock protein HSP 90-beta
ST13Hsc70-interacting protein

Protein metabolic processLAP3Cytosol aminopeptidase

Regulation of biological processIGFBP6Insulin-like growth factor-binding protein 6

Response to oxidative stressPRDX5Peroxiredoxin-5, mitochondrial

RNA splicingPTBP1Polypyrimidine tract-binding protein 1
PCBP1Poly(rC)-binding protein 1
SFPQSplicing factor, proline- and glutamine-rich

TranslationRPS2040S ribosomal protein S20

Carbohydrate metabolic processGLO1Lactoylglutathione lyase

GO: Gene Ontology.