Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance

Table 1

Protein contents of MSC-EVs.

Source of EVs	Protein	Function	Reference
Human bone marrow-derived MSCs	CD13, CD29, CD44, CD73, CD105, CD81, CD63, CD90, CD9	Surface antigen	[39–41]
Human bone marrow-derived MSCs	PDGFRB, EGFR, TGFBI, IGF2R	MSCs self-renewal	[39]
Human bone marrow-derived MSCs	CTNNBI, RAC1, RAC2, CHP, PRKCB, PPP2RIA, CAMK2D, PRKACA, CAMK2G	MSCs self-renewal and differentiation, Wnt signaling pathway	[39]
Human bone marrow-derived MSCs	PPP2RIA, MAPK1, USP9X, COL1A2, CD105, ENG	MSCs differentiation, TGFβ signaling pathway	[39]
Human bone marrow-derived MSCs	FLNA, HSPAB, CACNA2D1, CHP, FLNC, PDGFRB, RAP1B, RRAS2, MAP4K4, EGFR, RRAS, GNG12, RAC1, HSPAIA, CDC42, RAC2, NRAS, MAPKl, CD81, FLNB, HSPBl, PRKCB, PRKACA, RAP1A, GNAI2, CAVI, PRDX2, PPP2RIA, SOD1, ITGA1, LPAR1	MSCs differentiation, MAPK signaling pathway	[39]
Human bone marrow-derived MSCs	ILK, FABP5, ACSL4	MSCs differentiation, PPAR signaling pathway	[39]
Human bone marrow-derived MSCs	ENG, USP9X	MSCs differentiation, BMP signaling pathway	[39]
Human adipose tissue-derived MSCs	Neprilysin	Degrade intracellular and extracellular β-amyloid peptide in neuroblastoma cell lines	[42]
Human bone marrow-derived MSCs	TIA, TIAR, HuR	T cell internal antigen	[43]
Human bone marrow-derived MSCs	Stau1, Stau2	Involved in the transport and stability of mRNA	[43]
Human bone marrow-derived MSCs	Ago2	Involved in the miRNA transport and processing	[43]
Human umbilical cord-derived MSCs	Wnt4	Enhance the proliferation and migration	[43]
Human umbilical cord-derived MSCs	Angiogenin, IL-6, bFGF, UPAR, VEGF, MCP-1, VEGF R2, IGF-I	Promote angiogenesis	[44, 45]