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Stem Cells International
Volume 2017, Article ID 1798260, 11 pages
https://doi.org/10.1155/2017/1798260
Research Article

Therapeutic Effect and Location of GFP-Labeled Placental Mesenchymal Stem Cells on Hepatic Fibrosis in Rats

1State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Road, Hangzhou 310003, China
2Gansu Provincial Maternity and Child-Care Hospital, 143 Qilihe North Street, Lanzhou 730050, China
3Obstetrical Department, First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China
4Chu Kochen Honors College, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China

Correspondence should be addressed to Hongcui Cao; nc.ude.ujz@oacch

Received 24 January 2017; Accepted 8 March 2017; Published 12 April 2017

Academic Editor: Vladislav Volarevic

Copyright © 2017 Jiong Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Bataller and D. A. Brenner, “Liver fibrosis,” Journal of Clinical Investigation, vol. 115, no. 2, pp. 209–218, 2005. View at Publisher · View at Google Scholar
  2. R. Pais, A. S. Barritt, Y. Calmus et al., “NAFLD and liver transplantation: current burden and expected challenges,” Journal of Hepatology, vol. 65, no. 6, pp. 1245–1257, 2016. View at Publisher · View at Google Scholar
  3. G. Addolorato, A. Mirijello, P. Barrio, and A. Gual, “Treatment of alcohol use disorders in patients with alcoholic liver disease,” Journal of Hepatology, vol. 65, no. 3, pp. 618–630, 2016. View at Publisher · View at Google Scholar
  4. G. Ali, S. Mohsin, M. Khan et al., “Nitric oxide augments mesenchymal stem cell ability to repair liver fibrosis,” Journal of Translational Medicine, vol. 10, no. 1, p. 75, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. B. M. Stutchfield, S. J. Forbes, and S. J. Wigmore, “Prospects for stem cell transplantation in the treatment of hepatic disease,” Liver Transplantation, vol. 16, no. 7, pp. 827–836, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. A. R. Zekri, H. Salama, E. Medhat et al., “The impact of repeated autologous infusion of haematopoietic stem cells in patients with liver insufficiency,” Stem Cell Research & Therapy, vol. 6, no. 1, p. 118, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. O. Jang, M. Y. Kim, M. Y. Cho, S. K. Baik, Y. Z. Cho, and S. O. Kwon, “Effect of bone marrow-derived mesenchymal stem cells on hepatic fibrosis in a thioacetamide-induced cirrhotic rat model,” BMC Gastroenterology, no. 1, p. 14, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. H. Jiang, B. N. Jahagirdar, R. L. Reinhardt et al., “Pluripotency of mesenchymal stem cells derived from adult marrow,” Nature, vol. 418, pp. 41–49, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. P. S. In 't Anker, S. A. Scherjon, C. Kleijburg-van der Keur et al., “Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta,” Stem Cells, vol. 22, no. 7, pp. 1338–1345, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. O. K. Lee, T. K. Kuo, W. M. Chen, K. D. Lee, S. L. Hsieh, and T. H. Chen, “Isolation of multipotent mesenchymal stem cells from umbilical cord blood,” Blood, vol. 103, no. 5, pp. 1669–1675, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Miao, J. Jin, L. Chen et al., “Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells,” Cell Biology International, vol. 30, no. 9, pp. 681–687, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. H. C. Cao, J. F. Yang, J. Yu et al., “Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure,” BMC Medicine, no. 1, p. 10, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Parolini, F. Alviano, G. P. Bagnara et al., “Concise review: isolation and characterization of cells from human term placenta: outcome of the first international workshop on placenta derived stem cells,” Stem Cells, vol. 26, no. 2, pp. 300–311, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Mattar and K. Bieback, “Comparing the immunomodulatory properties of bone marrow, adipose tissue, and birth-associated tissue mesenchymal stromal cells,” Frontiers in Immunology, vol. 3, no. 6, p. 560, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Starkel and I. A. Leclercq, “Animal models for the study of hepatic fibrosis,” Best Practice & Research. Clinical Gastroenterology, vol. 25, no. 2, pp. 319–333, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Yu, X. Su, C. Zhu et al., “GFP labeling and hepatic differentiation potential of human placenta-derived Mesenchymal stem cells,” Cellular Physiology and Biochemistry, vol. 35, no. 6, pp. 2299–2308, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. W. K. Jeong, H. K. Lim, H. K. Lee, J. M. Jo, and Y. Kim, “Principles and clinical application of ultrasound elastography for diffuse liver disease,” Ultrasonography, vol. 33, no. 3, pp. 149–160, 2014. View at Publisher · View at Google Scholar
  18. T. Jiang, G. Tian, Q. Zhao et al., “Diagnostic accuracy of 2D-shear wave elastography for liver fibrosis severity: a meta-analysis,” PLoS One, vol. 11, no. 6, article e0157219, 2016. View at Publisher · View at Google Scholar
  19. M. Y. Kim, M. Y. Cho, S. K. Baik et al., “Histological subclassification of cirrhosis using the Laennec fibrosis scoring system correlates with clinical stage and grade of portal hypertension,” Journal of Hepatology, vol. 55, no. 5, pp. 1004–1009, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. M. D. Kim, S. S. Kim, H. Y. Cha et al., “Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis,” Experimental & Molecular Medicine, vol. 46, no. 8, article e110, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. W. H. Liu, F. Q. Song, L. N. Ren et al., “The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases,” Journal of Cellular and Molecular Medicine, vol. 19, no. 3, pp. 511–520, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Schuppan and M. Pinzani, “Anti-fibrotic therapy: lost in translation?” Journal of Hepatology, vol. 56, Supplement 1, pp. S66–S74, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. B. E. Van Beers, J. L. Daire, and P. Garteiser, “New imaging techniques for liver diseases,” Journal of Hepatology, vol. 62, no. 3, pp. 690–700, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. K. M. Moon, G. Kim, S. K. Baik et al., “Ultrasonographic scoring system score versus liver stiffness measurement in prediction of cirrhosis,” Clinical and Molecular Hepatology, vol. 19, no. 4, pp. 389–398, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Bedossa, G. Garcia-Tsao, and D. Jain, “Cirrhosis regression and subclassification,” Surgical Pathology Clinics, vol. 6, no. 2, pp. 295–309, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. F. J. Eng and S. L. Friedman, “Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex,” American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 279, no. 1, pp. G7–G11, 2000. View at Google Scholar
  27. S. Lindert, L. Wickert, I. Sawitza et al., “Transdifferentiation-dependent expression of alpha-SMA in hepatic stellate cells does not involve TGF-beta pathways leading to coinduction of collagen type I and thrombospondin-2,” Matrix Biology, vol. 24, no. 3, pp. 198–207, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Weiss and L. Attisano, “The TGFbeta superfamily signaling pathway,” Wiley Interdisciplinary Reviews: Developmental Biology, vol. 2, no. 1, pp. 47–63, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Dooley, B. Delvoux, B. Lahme, K. Mangasser-Stephan, and A. M. Gressner, “Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts,” Hepatology, vol. 31, no. 5, pp. 1094–1106, 2000. View at Publisher · View at Google Scholar
  30. G. R. Grotendorst, “Connective tissue growth factor: a mediator of TGF-β action on fibroblasts,” Cytokine & Growth Factor Reviews, vol. 8, no. 3, pp. 171–179, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Verrecchia and A. Mauviel, “Transforming growth factor-β and fibrosis,” World Journal of Gastroenterology, vol. 13, no. 22, pp. 3056–3062, 2007. View at Google Scholar
  32. K. Sakai, S. Jawaid, T. Sasaki, G. Bou-Gharios, and T. Sakai, “Transforming growth factor-beta-independent role of connective tissue growth factor in the development of liver fibrosis,” The American Journal of Pathology, vol. 184, no. 10, pp. 2611–2617, 2014. View at Publisher · View at Google Scholar · View at Scopus