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Stem Cells International
Volume 2017, Article ID 2014132, 9 pages
https://doi.org/10.1155/2017/2014132
Research Article

Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease

Department of Cryopathophysiology and Immunology, Institute for Problems of Cryobiology and Сryomedicine of the National Academy of Sciences of Ukraine, Pereyaslavskaya Str. 23, Kharkov 61015, Ukraine

Correspondence should be addressed to Mariia Yukhta; au.atem@yramavoppilif

Received 16 February 2017; Revised 15 June 2017; Accepted 17 July 2017; Published 27 August 2017

Academic Editor: Eva Mezey

Copyright © 2017 Nataliia Volkova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inflammatory disorders account for a significant percentage of gynecologic diseases, particularly in women of reproductive age. It is known that stem cells have anti-inflammatory and regenerative properties. Based on this, we investigated the effect of intravenous administration of cryopreserved mesenchymal stem cells (cMSCs) of bone marrow on experimental chronic inflammation of the ovaries. The paper shows that on the 21st day after cMSC therapy, leukocyte infiltration of ovaries was slightly relative to the control group without treatment, and the ratio of developing and atretic follicles in the animals with cMSC injection dramatically increased, while in the control, it still remained on the side of atretic forms. The number of apoptotic oocytes after stimulation of superovulation in the control group was significantly higher (85.3 ± 5.2%) than that in the animals with therapy (5.7 ± 0.8%). Relative number of fertilized eggs in the group with cMSC therapy was higher by 40% compare to that in the control. Pregnancy rate in natural estrous cycle after cell administration increased by 20%, and average number of litters in this group was two times significantly higher than that in the control. So the intravenous injection of cMSCs has the restorative effect on the fertility at experimental pelvic inflammatory disease.