Stem Cells International

Research Article

Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation

Table 4

Genes regulated by PEMF in mineralizing hBMSCs. Cells were from a normal 27-year-old female. Total RNA was isolated at day 33 of PEMF treatment. Analysis by Student’s t-test.
Gene symbolGene titleFold-change
(Avg PEMF versus avg controls)		p
Cell adhesion, motility, and cytoskeletal
COL1A2Collagen, type I, alpha 2
COL3A1Collagen, type III, alpha 1
FN1Fibronectin 1
FBN2Fibrillin 2
VIMVimentin
Transcriptional regulator, RNA metabolism, and RNA transport
MIR21MicroRNA 21
HNRNPA1 LOC728844Heterogeneous nuclear ribonucleoprotein
Cell cycle, cell growth, and apoptosis
CCNL1Cyclin L1
CCNL2Cyclin L2
Hormone, growth factor, and cytokine
CXCL12Chemokine (CXC motif) ligand 12 stromal cell-derived factor 1
IL15Interleukin 15
IL8Interleukin 8
TBRG1Transforming growth factor beta regulator 1
TGFB2Transforming growth factor, beta 2
Metabolic process
INSIG1Insulin induced gene 1
Signaling transduction, pathway
DAB2Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
THBS1thrombospondin 1
TIFATRAF-interacting protein with forkhead-associated domain
Protease and regulator
SERPINE1Serpin peptidase inhibitor, clade E member 1
BAG2BCL2-associated athanogene 2