An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma

Figure 2

Truncation and loss of Pax3 3′UTR during muscle stem cell self-renewal and RMS progression. (a) Schematic model of Pax3 and miR-1/206 expression during muscle stem cell self-renewal and activation. (b) Mouse Pax3 mRNA structures with short and long 3′UTRs and human RMS-derived PAX3-FOXO1 fusion gene.

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