An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma

Table 1

Deregulated miRNAs, their roles, targets, and expression in both alveolar and embryonic RMS.

Name	miRNA level in RMS relative; to normal human myoblasts		Target genes in RMS	Function	Reference
	Alveolar	Embryonal
miR-1	Down	Up	CCND2, cMET, PAX3	Tumor suppressor	[35, 36]
miR-24	Down	Down	—	—	[76]
miR-26a	Down	Down	Ezh2	Tumor suppressor	[36, 37, 76]
miR-27a	Down	Down	PAX3	Tumor suppressor	[36, 76]
miR-29	Down	Down	CCND2, PAX3, CCND2	Tumor suppressor	[36, 41]
miR-133a	Down	Down	TPM4	Tumor suppressor	[36, 76, 77]
miR-133b	Down	Down	—	Tumor suppressor	[36, 75]
miR-181	Down	Down	HOXA11	Tumor suppressor	[36, 42]
miR-183	Up	—	EGR1, PTEN	Oncogene	[36, 77]
miR-203	Down	Down	p63, LIF	Tumor suppressor	[43, 76]
miR-206	Down	Down	CCND2, cMET, PAX3	Tumor suppressor	[35, 75, 77]
miR-214	Down	Down	N-RAS	Tumor suppressor	[38, 44]
miR-301	Up	Up	—	Oncogene	[76]
miR-378a	Down	Down	IGF1R	Tumor suppressor	[45]
miR-450b	Down	Down	ENOX2, PAX9	Tumor suppressor	[44, 78]
miR-485	Up	—	NF-YB	Oncogene	[79]