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Stem Cells International
Volume 2017 (2017), Article ID 2857478, 12 pages
https://doi.org/10.1155/2017/2857478
Research Article

Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle

1Department of Cell Biology, Third Military Medical University, Chongqing 400038, China
2“111” Project Laboratory of Biomechanics and Tissue Repair and Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
3Chongqing Stem Cell Therapy Engineering Technical Center, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China

Correspondence should be addressed to Ke Yang; moc.361@41101287

Received 5 July 2016; Revised 4 January 2017; Accepted 24 January 2017; Published 27 February 2017

Academic Editor: Heinrich Sauer

Copyright © 2017 Haiying Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In Supplementary Figure 1 and 2, the expression pattern of sFRP4 in mouse dorsal skin was detected by immunofluorescence. In Supplementary Figure 3, the effect of sFRP4 on the pigmentation of hair follicle was detected. The result showed that the skin eventually turned black when sFRP4 administration was ceased. In Supplementary Figure 4, the effect of sFRP4 on the differentiation of hair follicle cells was examined. The result showed that the differentiated cells were reduced after sFRP4 treatment. In Supplementary Figure 5, the effect of sFRP4 on the proliferation of hair follicle cells was examined. The result showed that the proliferated cells were reduced after sFRP4 treatment. 

  1. Supplementary Material