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Stem Cells International
Volume 2017 (2017), Article ID 3250624, 13 pages
https://doi.org/10.1155/2017/3250624
Review Article

When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells

1State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300371, China
2College of Pharmacy, Nankai University, Tianjin 300350, China

Correspondence should be addressed to Xinyi Lu; nc.ude.iaknan@yxul

Received 30 August 2017; Accepted 25 October 2017; Published 23 November 2017

Academic Editor: Qiang Wu

Copyright © 2017 Fuquan Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Most of the human genome can be transcribed into RNAs, but only a minority of these regions produce protein-coding mRNAs whereas the remaining regions are transcribed into noncoding RNAs. Long noncoding RNAs (lncRNAs) were known for their influential regulatory roles in multiple biological processes such as imprinting, dosage compensation, transcriptional regulation, and splicing. The physiological functions of protein-coding genes have been extensively characterized through genome editing in pluripotent stem cells (PSCs) in the past 30 years; however, the study of lncRNAs with genome editing technologies only came into attentions in recent years. Here, we summarize recent advancements in dissecting the roles of lncRNAs with genome editing technologies in PSCs and highlight potential genome editing tools useful for examining the functions of lncRNAs in PSCs.