Potential applications of the CRISPR/Cas9 system to study lncRNAs in PSCs. Application of CRISPR/Cas9 technology in the (a) repression of lncRNA transcription, (b) activation of lncRNA expression, (c) recruitment of the lncRNA to chromatin, and (d) isolation of the lncRNA-protein complex. (e) Degradation of the lncRNA. (f) Monitoring lncRNA localization. Green strand: gRNA.