When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells

Table 1

Introduction of different lncRNA databases.

Name	Date	Species	Function	Website	Ref.
Comprehensive annotations of lncRNAs
NONCODE	2005	17 species	Gene function annotation	http://www.noncode.org/	[9]
lncRNAdb	2011	68 species	Comprehensive annotations of functional lncRNAs	http://www.lncrnadb.org/	[29]
lncRNome	2013	Human	Integrating annotations on a wide variety of biologically significant information	http://genome.igib.res.in/lncRNome/	[30]
lncRNAtor	2014	6 species	Functional investigation of lncRNAs	http://lncrnator.ewha.ac.kr/	[31]
LncRNAWiki	2015	Human	Comprehensive integration of information on human lncRNAs	http://lncrna.big.ac.cn	[32]
Annotation of lncRNA interactions
LNCipedia	2013	Human	Annotation of lncRNA transcript sequences and structures	https://www.lncipedia.org	[33]
Linc2GO	2013	Human	lincRNA function annotation based on ceRNA hypothesis	–	[34]
Starbase	2014	Human, mouse, and C. elegans	Annotation of miRNA-lncRNA/mRNA interactions	–	[35]
NPInter	2014	18 species	Interactions between ncRNAs and biomolecules	http://www.bioinfo.org/NPInter	[36]
lncACTdb	2015	Human	lncRNA-miRNA-gene interactions	–	[37]
Transcriptional regulatory networks of lncRNAs
ChIPBase	2013	6 species	Transcriptional regulatory networks of ncRNAs and PCGs	–	[38]
SNP@lincTFBS	2014	Human	Annotation of SNPs in potential TFBSs of lincRNAs	http://bioinfo.hrbmu.edu.cn/SNP_lincTFBS	[39]
TF2LncRNA	2014	Human	Identifying common transcription factors of lncRNAs	–	[40]
lncRNA-associated pathways
LncReg	2015	Human and mouse	lncRNA-associated regulatory networks	http://bioinformatics.ustc.edu.cn/lncreg/	[41]
Co-LncRNA	2015	Human	Investigating the lncRNA combinatorial effects in GO annotations and KEGG pathways	http://www.bio-bigdata.com/Co-LncRNA//lncreg/	[42]
lncRNA-disease associations
C-It-Loci	2015	Human, mouse, and zebrafish	Tissue-specific lncRNAs	http://c-it-loci.uni-frankfurt.de	[43]
LncRNADisease	2013	Human	lncRNA-disease associations	–	[44]
lnCaNet	2016	Human	lncRNA-cancer gene coexpression network	http://lncanet.bioinfo-minzhao.org/	[45]
Lnc2Cancer	2016	Human	Exploring lncRNA deregulation in various cancers	http://www.bio-bigdata.net/lnc2cancer	[46]