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Stem Cells International
Volume 2017 (2017), Article ID 3258035, 9 pages
https://doi.org/10.1155/2017/3258035
Research Article

The Optimal Intervention Time of Bone Marrow Mesenchymal Stem Cells in Ameliorating Cardiac Fibrosis Induced by Viral Myocarditis: A Randomized Controlled Trial in Mice

Children’s Heart Center, The Second Affiliated Hospital and Yuying Children’s Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China

Correspondence should be addressed to Rongzhou Wu; moc.liamtoh@17zrw

Received 28 April 2017; Revised 30 August 2017; Accepted 11 October 2017; Published 5 December 2017

Academic Editor: Benedetta Bussolati

Copyright © 2017 Tingting Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Pollack, A. R. Kontorovich, V. Fuster, and G. W. Dec, “Viral myocarditis—diagnosis, treatment options, and current controversies,” Nature Reviews Cardiology, vol. 12, no. 11, pp. 670–680, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Yajima and K. U. Knowlton, “Viral myocarditis: from the perspective of the virus,” Circulation, vol. 119, no. 19, pp. 2615–2624, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. C. R. Ellis and T. di Salvo, “Myocarditis: basic and clinical aspects,” Cardiology in Review, vol. 15, no. 4, pp. 170–177, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Di Filippo, “Improving outcomes of acute myocarditis in children,” Expert Review of Cardiovascular Therapy, vol. 14, no. 1, pp. 117–125, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Gaaloul, S. Riabi, M. Evans, T. Hunter, S. Huber, and M. Aouni, “Postmortem diagnosis of infectious heart diseases: a mystifying cause of sudden infant death,” Forensic Science International, vol. 262, pp. 166–172, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Brunetti and E. R. H. DeSantis, “Treatment of viral myocarditis caused by coxsackievirus B,” American Journal of Health-System Pharmacy, vol. 65, no. 2, pp. 132–137, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. T. F. Huang, X. H. Wu, X. Wang, and I. J. Lu, “Fas-FasL expression and myocardial cell apoptosis in patients with viral myocarditis,” Genetics and Molecular Research, vol. 15, no. 2, pp. 1–8, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Pontikoglou, F. Deschaseaux, L. Sensebé, and H. A. Papadaki, “Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation,” Stem Cell Reviews and Reports, vol. 7, no. 3, pp. 569–589, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Zhuang, X. Zhang, C. Zhu et al., “Molecular mechanisms of PPAR-γ governing MSC osteogenic and adipogenic differentiation,” Current Stem Cell Research & Therapy, vol. 11, no. 3, pp. 255–264, 2016. View at Publisher · View at Google Scholar
  10. J. D. Glenn and K. A. Whartenby, “Mesenchymal stem cells: emerging mechanisms of immunomodulation and therapy,” World Journal of Stem Cells, vol. 6, no. 5, pp. 526–539, 2014. View at Publisher · View at Google Scholar
  11. F. Pourrajab, S. K. Forouzannia, and S. A. Tabatabaee, “Molecular characteristics of bone marrow mesenchymal stem cells, source of regenerative medicine,” International Journal of Cardiology, vol. 163, no. 2, pp. 125–131, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Golpanian, A. Wolf, K. E. Hatzistergos, and J. M. Hare, “Rebuilding the damaged heart: Mesenchymal stem cells, cell-based therapy, and engineered heart tissue,” Physiological Reviews, vol. 96, no. 3, pp. 1127–1168, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. Z. Zhang, J. Yang, W. Yan, Y. Li, Z. Shen, and T. Asahara, “Pretreatment of cardiac stem cells with exosomes derived from mesenchymal stem cells enhances myocardial repair,” Journal of the American Heart Association, vol. 5, no. 1, pp. 1–16, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Teng, L. Chen, W. Chen, J. Yang, Z. Yang, and Z. Shen, “Mesenchymal stem cell-derived Exosomes improve the microenvironment of infarcted myocardium contributing to angiogenesis and anti-inflammation,” Cellular Physiology and Biochemistry, vol. 37, no. 6, pp. 2415–2424, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. V. B. R. Konala, M. K. Mamidi, R. Bhonde, A. K. Das, R. Pochampally, and R. Pal, “The current landscape of the mesenchymal stromal cell secretome: a new paradigm for cell-free regeneration,” Cytotherapy, vol. 18, no. 1, pp. 13–24, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Huang, W. Ma, Y. Ma, D. Feng, H. Chen, and B. Cai, “Exosomes in mesenchymal stem cells, a new therapeutic strategy for cardiovascular diseases?” International Journal of Biological Sciences, vol. 11, no. 2, pp. 238–245, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Cai, R. Shen, L. Song et al., “Bone marrow mesenchymal stem cells (BM-MSCs) improve heart function in swine myocardial infarction model through paracrine effects,” Scientific Reports, vol. 6, no. 1, article 28250, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Rezkalla, R. A. Kloner, G. Khatib, F. E. Smith, and R. Khatib, “Effect of metoprolol on the acute phase of coxsackievirus B3 murine myocarditis,” Journal of the American College of Cardiology, vol. 12, no. 2, pp. 412–414, 1988. View at Google Scholar
  19. A. L. P. Caforio, G. Malipiero, R. Marcolongo, and S. Iliceto, “Myocarditis: a clinical overview,” Current Cardiology Reports, vol. 19, no. 7, p. 63, 2017. View at Publisher · View at Google Scholar
  20. P. M. Becher, F. Gotzhein, and K. Klingel, “Cardiac function remains impaired despite reversible cardiac remodeling after acute experimental viral myocarditis,” Journal of Immunology Research, vol. 2017, Article ID 6590609, 17 pages, 2017. View at Publisher · View at Google Scholar
  21. L. Yue-Chun, C. Guang-Yi, G. Li-Sha et al., “The protective effects of Ivabradine in preventing progression from viral myocarditis to dilated cardiomyopathy,” Frontiers in Pharmacology, vol. 7, p. 408, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Chen, R. Xia, Z. Li et al., “Mesenchymal stem cells combined with hepatocyte growth factor therapy for attenuating ischaemic myocardial fibrosis: assessment using multimodal molecular imaging,” Scientific Reports, vol. 6, no. 1, article 33700, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Ishikawa, J. Jo, and Y. Tabata, “Liver anti-fibrosis therapy with mesenchymal stem cells secreting hepatocyte growth factor,” Journal of Biomaterials Science Polymer Edition, vol. 23, no. 18, pp. 2259–2272, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Mias, O. Lairez, E. Trouche et al., “Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction,” Stem Cells, vol. 27, no. 11, pp. 2734–2743, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. S. H. Chou, S. Z. Lin, W. W. Kuo et al., “Mesenchymal stem cell insights: prospects in cardiovascular therapy,” Cell Transplantation, vol. 23, no. 4-5, pp. 513–529, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Kyurkchiev, I. Bochev, E. Ivanova-Todorova et al., “Secretion of immunoregulatory cytokines by mesenchymal stem cells,” World Journal of Stem Cells, vol. 6, no. 5, pp. 552–570, 2014. View at Publisher · View at Google Scholar
  27. Y. Wang, X. Chen, W. Cao, and Y. Shi, “Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications,” Nature Immunology, vol. 15, no. 11, pp. 1009–1016, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Li and J. Hua, “Interactions between mesenchymal stem cells and the immune system,” Cellular and Molecular Life Sciences, vol. 74, no. 13, pp. 2345–2360, 2017. View at Publisher · View at Google Scholar
  29. L. Zhao, S. Li, J. Ge, A. Sun, Y. Zou, and S. Zhang, “Temporal changes in stem cells in the circulation and myocardium of mice with Coxsackie virus B3-induced myocarditis,” Microvascular Research, vol. 75, no. 3, pp. 358–366, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Speca, I. Giusti, F. Rieder, and G. Latella, “Cellular and molecular mechanisms of intestinal fibrosis,” World Journal of Gastroenterology, vol. 18, no. 28, pp. 3635–3661, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. X. M. Meng, D. J. Nikolic-Paterson, and H. Y. Lan, “TGF-β: the master regulator of fibrosis,” Nature Reviews Nephrology, vol. 12, no. 6, pp. 325–338, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Yoshimatsu and T. Watabe, “Roles of TGF-β signals in endothelial-mesenchymal transition during cardiac fibrosis,” International Journal of Inflammation, vol. 2011, Article ID 724080, 8 pages, 2011. View at Publisher · View at Google Scholar
  33. Y. Guo, M. Gupte, P. Umbarkar et al., “Entanglement of GSK-3β, β-catenin and TGF-β1 signaling network to regulate myocardial fibrosis,” Journal of Molecular and Cellular Cardiology, vol. 110, pp. 109–120, 2017. View at Publisher · View at Google Scholar
  34. X. H. Sun, J. Fu, and D. Q. Sun, “Halofuginone alleviates acute viral myocarditis in suckling BALB/c mice by inhibiting TGF-β1,” Biochemical and Biophysical Research Communications, vol. 473, no. 2, pp. 558–564, 2016. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Chen, Y. Xie, E. Shen et al., “Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy,” European Journal of Pharmacology, vol. 658, no. 2-3, pp. 168–174, 2011. View at Publisher · View at Google Scholar · View at Scopus