A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke

Figure 1

This figure demonstrates neurogenesis of endogenous neural stem cells. (1) Neurogenesis and proliferation occur in the SVZ and SGZ on the lateral ventricle and hippocampus, respectively. (2) NSPC migration occurs through the rostral migratory stream to the olfactory bulb, where neuroblasts migrate as interneurons through specific cell layers. From the SGZ, NSPCs migrate to the inner granule cell layer. (3) Differentiation occurs once neuroblasts reach glomeruli within the olfactory bulb or the inner granule cell layer. The majority of SVZ-derived neuroblasts become GABAergic granule neurons. After complete differentiation and maturation of neuroblasts from the SGZ, new neurons possess GABAergic and glutamatergic characteristics.