Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy

Figure 7

Gal-3 knockdown impairs T. cruzi infectivity in vitro. (a) Gene expression of Gal-3 is increased 48 h and 72 h after infection of MSC-WT with T. cruzi. (b) Percentage of T. cruzi infection in MSC-WT and MSC-Gal3KD lines during the first 72 h. (c) Percentage of infection and (d) number of parasites per cell in J774 macrophages nontransduced (WT) or transduced with control vector (Ctrl) or Gal-3 shRNA (Gal3 KD). ; ; .

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