Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice

<div>Experimental design and technical set-up. (a) The schedule of animal experiments in this study. (b) The representative expression of ChR2-mCherry opsins in striatal neurons under CaMKII promoter. (c) The schematic representation of the structure of lab-made optrode. (d) The hardware system for synchronous laser stimulation and electrophysiological recording. (e) The characterization of cultured NSC-GFP sphere by immunohistochemical staining with NSC markers SOX2 and Nestin. Bar = 100 <i>μ</i>m.</div>

Stem Cells International

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Figure 1

Figure 1: Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice 

Figure 1 | Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice 