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Stem Cells International
Volume 2017, Article ID 4378947, 8 pages
https://doi.org/10.1155/2017/4378947
Review Article

Urine-Derived Stem Cells: The Present and the Future

1Department of Central Laboratory, Shanghai Children’s Hospital, Shanghai Jiao Tong University, 1400 Beijing Road West, Shanghai 200040, China
2Department of Urology, Shanghai Children’s Hospital, Shanghai Jiao Tong University, 1400 Beijing Road West, Shanghai 200040, China

Correspondence should be addressed to Junmei Zhou; moc.931@uohz_iemnuj

Received 30 June 2017; Revised 30 August 2017; Accepted 7 September 2017; Published 8 November 2017

Academic Editor: Ming Li

Copyright © 2017 Xiaoli Ji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Morrison, “Advancing stem cell science and translation,” Stem Cell Reports, vol. 6, no. 6, pp. 785-786, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Atala, “Advancing the translation of stem cells to medicine,” Stem Cells Translational Medicine, vol. 6, no. 1, pp. 1-2, 2017. View at Publisher · View at Google Scholar
  3. J. A. Thomson, J. Itskovitz-Eldor, S. S. Shapiro et al., “Embryonic stem cell lines derived from human blastocysts,” Science, vol. 282, no. 5391, pp. 1145–1147, 1998. View at Publisher · View at Google Scholar
  4. K. Takahashi, K. Tanabe, M. Ohnuki et al., “Induction of pluripotent stem cells from adult human fibroblasts by defined factors,” Cell, vol. 131, no. 5, pp. 861–872, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Yu, M. A. Vodyanik, K. Smuga-Otto et al., “Induced pluripotent stem cell lines derived from human somatic cells,” Science, vol. 318, no. 5858, pp. 1917–1920, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Liu, J. Zhou, X. Zhang et al., “Strategies to optimize adult stem cell therapy for tissue regeneration,” International Journal of Molecular Sciences, vol. 6, p. 17, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. G. I. Im, “Bone marrow-derived stem/stromal cells and adipose tissue-derived stem/stromal cells: their comparative efficacies and synergistic effects,” Journal of Biomedical Materials Research Part A, vol. 105, no. 9, pp. 2640–2648, 2017. View at Publisher · View at Google Scholar
  8. A. El-Badawy, S. M. Ahmed, and N. El-Badri, “Adipose-derived stem cell-based therapies in regenerative medicine,” Advances in Stem Cell Therapy, pp. 117–138, 2017. View at Publisher · View at Google Scholar
  9. J. H. Arrizabalaga and M. U. Nollert, “Properties of porcine adipose-derived stem cells and their applications in preclinical models,” Adipocytes, vol. 6, no. 3, pp. 217–223, 2017. View at Publisher · View at Google Scholar
  10. Y. Zhang, E. McNeill, H. Tian et al., “Urine derived cells are a potential source for urological tissue reconstruction,” Journal of Urology, vol. 180, no. 5, pp. 2226–2233, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Zhang, G. Wei, P. Li, X. Zhou, and Y. Zhang, “Urine-derived stem cells: a novel and versatile progenitor source for cell-based therapy and regenerative medicine,” Genes & Diseases, vol. 1, no. 1, pp. 8–17, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Liu, C. Deng, and Y. Zhang, “Urine-derived stem cells: biological characterization and potential clinical applications,” Stem Cells: Current Challenges and New Directions, pp. 19–28, 2013. View at Publisher · View at Google Scholar
  13. B. Bussolati and G. Camussi, “Therapeutic use of human renal progenitor cells for kidney regeneration,” Nature Reviews Nephrology, vol. 11, no. 12, pp. 695–706, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Oliveira Arcolino, A. Tort Piella, E. Papadimitriou et al., “Human urine as a noninvasive source of kidney cells,” Stem Cells International, vol. 2015, Article ID 362562, 7 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Bharadwaj, G. Liu, Y. Shi et al., “Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology,” Stem Cells, vol. 31, no. 9, pp. 1840–1856, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Jouni, K. Si-Tayeb, Z. Es-Salah-Lamoureux et al., “Toward personalized medicine: using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of type 2 long QT syndrome,” Journal of the American Heart Association, vol. 4, no. 9, article e002159, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Shi, Y. Cui, J. Luan, X. Zhou, and J. Han, “Urine-derived induced pluripotent stem cells as a modeling tool to study rare human diseases,” Intractable & Rare Diseases Research, vol. 5, no. 3, pp. 192–201, 2016. View at Publisher · View at Google Scholar
  18. G. R. Sutherland and A. D. Bain, “Culture of cells from the urine of newborn children,” Nature, vol. 239, no. 5369, p. 231, 1972. View at Publisher · View at Google Scholar · View at Scopus
  19. J. J. Guan, X. Niu, F. X. Gong et al., “Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology,” Tissue Engineering Part A, vol. 20, no. 13-14, pp. 1794–1806, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Z. Zhang, L. X. Ma, W. J. Qian, H. F. Li, and Z. F. Wang, “Modeling neurological disease by rapid conversion of human urine cells into functional neurons,” Stem Cells International, vol. 2016, Article ID 2452985, 8 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Guan, J. Zhang, Z. Zhu et al., “Bone morphogenetic protein 2 gene transduction enhances the osteogenic potential of human urine-derived stem cells,” Stem Cell Research & Therapy, vol. 6, p. 5, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Guan, J. Zhang, S. Guo et al., “Human urine-derived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt/β-catenin signaling pathway,” Biomaterials, vol. 55, pp. 1–11, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Guan, J. Zhang, H. Li et al., “Human urine derived stem cells in combination with β-TCP can be applied for bone regeneration,” PLoS One, vol. 10, no. 5, article e0125253, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Y. Kim, P. Page, L. M. Dellefave-Castillo, E. M. McNally, and E. J. Wyatt, “Direct reprogramming of urine-derived cells with inducible Myod for modeling human muscle disease,” Skeletal Muscle, vol. 6, p. 32, 2016. View at Publisher · View at Google Scholar · View at Scopus
  25. W. Chen, M. Xie, B. Yang et al., “Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration,” Journal of Tissue Engineering and Regenerative Medicine, vol. 11, no. 2, pp. 334–341, 2017. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Liu, X. Wang, X. Sun, C. Deng, A. Atala, and Y. Zhang, “The effect of urine-derived stem cells expressing VEGF loaded in collagen hydrogels on myogenesis and innervation following after subcutaneous implantation in nude mice,” Biomaterials, vol. 34, no. 34, pp. 8617–8629, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Ramsay, C. Ringuette-Goulet, A. Langlois, and S. Bolduc, “Clinical challenges in tissue-engineered urethral reconstruction,” Translational Andrology and Urology, vol. 5, no. 2, pp. 267–270, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Liu, W. Ma, B. Liu et al., “Urethral reconstruction with autologous urine-derived stem cells seeded in three-dimensional porous small intestinal submucosa in a rabbit model,” Stem Cell Research & Therapy, vol. 8, no. 1, p. 63, 2017. View at Publisher · View at Google Scholar
  29. L. R. Versteegden, P. K. de Jonge, J. IntHout et al., “Tissue engineering of the urethra: a systematic review and meta-analysis of preclinical and clinical studies,” European Urology, vol. 72, no. 4, pp. 594–606, 2017. View at Publisher · View at Google Scholar
  30. P. Gao, D. Jiang, W. Liu, H. Li, and Z. Li, “Urine-derived stem cells, a new source of seed cells for tissue engineering,” Current Stem Cell Research & Therapy, vol. 11, no. 7, pp. 547–553, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Liu, F. Ding, Y. Liu, G. Xiong, T. Lin, and D. He, “Urine-derived stem cells: a novel source for tissue engineering and regenerative medicine,” Journal of Biomaterials and Tissue Engineering, vol. 6, no. 8, pp. 589–601, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Y. Chan, S. K. Sandlin, E. A. Kurzrock, and S. L. Osborn, “The current use of stem cells in bladder tissue regeneration and bioengineering,” Biomedicine, vol. 5, no. 1, 2017. View at Publisher · View at Google Scholar
  33. A. Bodin, S. Bharadwaj, S. Wu, P. Gatenholm, A. Atala, and Y. Zhang, “Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion,” Biomaterials, vol. 31, no. 34, pp. 8889–8901, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. Z. Tong, C. Cao, M. Rao, and J. Lu, “Potential cell source for cell- based therapy and tissue engineering applications: urine-derived stem cells,” Journal of Biomaterials and Tissue Engineering, vol. 5, no. 2, pp. 150–156, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. I. H. Park, N. Arora, H. Huo et al., “Disease-specific induced pluripotent stem cells,” Cell, vol. 134, no. 5, pp. 877–886, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. D. L. Mack, X. Guan, A. Wagoner, S. J. Walker, and M. K. Childers, “Disease-in-a-dish: the contribution of patient-specific induced pluripotent stem cell technology to regenerative rehabilitation,” American Journal of Physical Medicine & Rehabilitation, vol. 93, Supplement 3, no. 11, pp. S155–S168, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Avior, I. Sagi, and N. Benvenisty, “Pluripotent stem cells in disease modelling and drug discovery,” Nature Reviews Molecular Cell Biology, vol. 17, no. 3, pp. 170–182, 2016. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Zhou, C. Benda, S. Dunzinger et al., “Generation of human induced pluripotent stem cells from urine samples,” Nature Protocols, vol. 7, no. 12, pp. 2080–2089, 2012. View at Publisher · View at Google Scholar
  39. T. Zhou, C. Benda, S. Duzinger et al., “Generation of induced pluripotent stem cells from urine,” Journal of American Society of Nephrology, vol. 22, no. 7, pp. 1221–1228, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. E. Mizutani, K. Torikai, S. Wakayama et al., “Generation of cloned mice and nuclear transfer embryonic stem cell lines from urine-derived cells,” Scientific Reports, vol. 6, article 23808, 2016. View at Publisher · View at Google Scholar · View at Scopus
  41. D. Guo, F. Wu, H. Liu et al., “Generation of non-integrated induced pluripotent stem cells from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome,” Stem Cell Research, vol. 18, pp. 70–72, 2017. View at Publisher · View at Google Scholar · View at Scopus
  42. D. Guo, F. Wu, H. Liu et al., “Generation of non-integrated induced pluripotent stem cells from a 59-year-old female with multiple endocrine neoplasia type 1 syndrome,” Stem Cell Research, vol. 18, pp. 64–66, 2017. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Z. Afzal, M. Gartz, E. A. Klyachko et al., “Generation of human iPSCS from urine derived cells of patient with a novel heterozygous PAI-1 mutation,” Stem Cell Research, vol. 18, pp. 41–44, 2017. View at Publisher · View at Google Scholar
  44. M. Z. Afzal, M. Gartz, E. A. Klyachko et al., “Generation of human iPSCs from urine derived cells of a non-affected control subject,” Stem Cell Research, vol. 18, pp. 33–36, 2017. View at Publisher · View at Google Scholar
  45. B. Jia, S. Chen, Z. Zhao et al., “Modeling of hemophilia a using patient-specific induced pluripotent stem cells derived from urine cells,” Life Sciences, vol. 108, no. 1, pp. 22–29, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. Y. M. Lee, B. L. Zampieri, J. J. Scott-McKean, M. W. Johnson, and A. C. S. Costa, “Generation of integration-free induced pluripotent stem cells from urine-derived cells isolated from individuals with Down syndrome,” Stem Cells Translational Medicine, vol. 6, no. 6, pp. 1465–1476, 2017. View at Publisher · View at Google Scholar
  47. Y. Liu, Y. Zheng, S. Li et al., “Human neural progenitors derived from integration-free iPSCs for SCI therapy,” Stem Cell Research, vol. 19, pp. 55–64, 2017. View at Publisher · View at Google Scholar
  48. J. Sochacki, S. Devalle, M. Reis, P. Mattos, and S. Rehen, “Generation of urine iPS cell lines from patients with attention deficit hyperactivity disorder (ADHD) using a non-integrative method,” Stem Cell Research, vol. 17, no. 1, pp. 102–106, 2016. View at Publisher · View at Google Scholar · View at Scopus
  49. Y. H. Lin, X. M. Chen, J. W. Zhang, X. Q. He, W. J. Dai, and M. S. Chen, “Preclinical study on induction of pluripotent stem cells from urine of dilated cardiomyopathy patients,” European Review for Medical and Pharmacological Sciences, vol. 20, no. 8, pp. 1450–1457, 2016. View at Google Scholar
  50. M. Z. Afzal and J. L. Strande, “Generation of induced pluripotent stem cells from muscular dystrophy patients: efficient integration-free reprogramming of urine derived cells,” Journal of Visualized Experiments, no. 95, article 52032, 2015. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Cai, V. V. Orlova, X. Cai et al., “Induced pluripotent stem cells to model human fibrodysplasia ossificans progressiva,” Stem Cell Reports, vol. 5, no. 6, pp. 963–970, 2015. View at Publisher · View at Google Scholar · View at Scopus
  52. L. Hildebrand, B. Rossbach, P. Kuhnen et al., “Generation of integration free induced pluripotent stem cells from fibrodysplasia ossificans progressiva (FOP) patients from urine samples,” Stem Cell Research, vol. 16, no. 1, pp. 54–58, 2016. View at Publisher · View at Google Scholar · View at Scopus
  53. Y. Chen, R. Luo, Y. Xu et al., “Generation of systemic lupus erythematosus-specific induced pluripotent stem cells from urine,” Rheumatology International, vol. 33, no. 8, pp. 2127–2134, 2013. View at Publisher · View at Google Scholar · View at Scopus
  54. J. Zhou, X. Wang, S. Zhang et al., “Generation and characterization of human cryptorchid-specific induced pluripotent stem cells from urine,” Stem Cells Development, vol. 22, no. 5, pp. 717–725, 2013. View at Publisher · View at Google Scholar · View at Scopus
  55. K. Si-Tayeb, S. Idriss, B. Champon et al., “Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia,” Disease Models & Mechanisms, vol. 9, no. 1, pp. 81–90, 2016. View at Publisher · View at Google Scholar · View at Scopus
  56. S. Z. Zhang, H. F. Li, L. X. Ma, W. J. Qian, Z. F. Wang, and Z. Y. Wu, “Urine-derived induced pluripotent stem cells as a modeling tool for paroxysmal kinesigenic dyskinesia,” Biology Open, vol. 4, no. 12, pp. 1744–1752, 2015. View at Publisher · View at Google Scholar · View at Scopus
  57. P. A. Lee and C. P. Houk, “Cryptorchidism,” Current Opinion in Endocrinology, Diabetes & Obesity, vol. 20, no. 3, pp. 210–216, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. J. M. Polo, S. Liu, M. E. Figueroa et al., “Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells,” Nature Biotechnology, vol. 28, no. 8, pp. 848–855, 2010. View at Publisher · View at Google Scholar · View at Scopus
  59. F. Rouhani, N. Kumasaka, M. C. de Brito, A. Bradley, L. Vallier, and D. Gaffney, “Genetic background drives transcriptional variation in human induced pluripotent stem cells,” PLoS Genetics, vol. 10, no. 6, article e1004432, 2014. View at Publisher · View at Google Scholar · View at Scopus
  60. K. Kim, A. Doi, B. Wen et al., “Epigenetic memory in induced pluripotent stem cells,” Nature, vol. 467, no. 7313, pp. 285–290, 2010. View at Publisher · View at Google Scholar · View at Scopus