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Stem Cells International
Volume 2017 (2017), Article ID 4653936, 7 pages
https://doi.org/10.1155/2017/4653936
Review Article

Neuroprotective Effects of Stem Cells in Ischemic Stroke

1Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
2Brain Research Institute, Zhejiang University, Hangzhou, Zhejiang, China
3Collaborative Innovation Center for Brain Science, Zhejiang University, Hangzhou, Zhejiang, China

Correspondence should be addressed to Jianmin Zhang and Anwen Shao

Received 27 April 2017; Accepted 11 June 2017; Published 3 July 2017

Academic Editor: Hailiang Tang

Copyright © 2017 Weilin Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ischemic stroke, the most common subtype of stroke, has been one of the leading causes of mobility and mortality worldwide. However, it is still lacking of efficient agents. Stem cell therapy, with its vigorous advantages, has attracted researchers around the world. Numerous experimental researches in animal models of stroke have demonstrated the promising efficacy in treating ischemic stroke. The underlying mechanism involved antiapoptosis, anti-inflammation, promotion of angiogenesis and neurogenesis, formation of new neural cells and neuronal circuitry, antioxidation, and blood-brain barrier (BBB) protection. This review would focus on the types and neuroprotective actions of stem cells and its potential mechanisms for ischemic stroke.