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Stem Cells International
Volume 2017, Article ID 5091541, 13 pages
https://doi.org/10.1155/2017/5091541
Research Article

Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer

1Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
2College of Pharmacy, Taishan Medical University, Tai’an, Shandong, China
3Department of Breast Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei, China
4The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA

Correspondence should be addressed to Yulong Liang; ude.mcb@gnoluy

Received 2 November 2016; Revised 5 January 2017; Accepted 17 January 2017; Published 14 March 2017

Academic Editor: Tong-Chuan He

Copyright © 2017 Chuanwei Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary information contains 5 supplementary figures (Figure S1 to S5) and 4 supplementary tables (Table S1 to S4). Figure S1 and S2 show the alterations of all 27 CDHs in all breast cancer samples and TNBC samples from TCGA respectively. Figure S3 shows alteration of top 24 genes while Figure S4 demonstrates alterations of 7 stem cell-related transcription factors in breast cancer samples used for analysis. FigureS5 shows representative data of Figure 3C. Table S1 and S2 demonstrate the correlation of altered CDH1 and expressions of ESR1, PGR and HER2 or stem cell-related transcription factors respectively. Table S3 lists genes enriched with altered CDHs in breast cancer samples. Table S4 describes correlation between stem cell-related transcription factors and ESR1, PGR and HER2 status in breast cancer using RPPA dataset.

  1. Supplementary Material