Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer

Table 5

Top 10 perturbagens identified through the Connectivity Map that induce the CDH-associated signature.

Pharmaceutical perturbagen	Enrichment CMap score			value	Description
Trimethobenzamide	0.885	5	5	0.00006	An antiemetic used to prevent nausea and vomiting
Felbinac	0.892	7	4	0.00012	A nonsteroidal anti-inflammatory drug of the arylacetic acid class
Iopamidol	0.886	8	4	0.00018	A radiopaque contrast agent
Diethylstilbestrol	0.738	13	6	0.00085	A synthetic, nonsteroidal estrogen, and a potent agonist of estrogen receptors
Adiphenine	0.789	14	5	0.00092	An inhibitor of nicotinic receptors
Paclitaxel	0.728	17	6	0.00107	A microtubule-damaging agent, affecting mitosis
Thioperamide	0.754	20	5	0.00216	A potent antagonist of histamine receptor H3/H4
Cinchonine	0.813	21	4	0.00237	A multidrug resistance-reversing agent
Diphenhydramine	0.737	25	5	0.00290	An antihistamine agent
Vinburnine	0.796	28	4	0.00334	A vinca alkaloid acting as a vasodilator

Note. by value. indicates the number of instances related to this perturbagen tested in the Connectivity Map.