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Stem Cells International
Volume 2017, Article ID 5173732, 16 pages
https://doi.org/10.1155/2017/5173732
Review Article

Mesenchymal Stem and Progenitor Cells in Regeneration: Tissue Specificity and Regenerative Potential

1Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria
2Center for Medical Research (ZMF), Medical University of Graz, Graz, Austria

Correspondence should be addressed to Rokhsareh Rohban; ta.zarginudem@nabhor.nerashkor

Received 14 October 2016; Accepted 7 December 2016; Published 13 February 2017

Academic Editor: Andrea Ballini

Copyright © 2017 Rokhsareh Rohban and Thomas Rudolf Pieber. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It has always been an ambitious goal in medicine to repair or replace morbid tissues for regaining the organ functionality. This challenge has recently gained momentum through considerable progress in understanding the biological concept of the regenerative potential of stem cells. Routine therapeutic procedures are about to shift towards the use of biological and molecular armamentarium. The potential use of embryonic stem cells and invention of induced pluripotent stem cells raised hope for clinical regenerative purposes; however, the use of these interventions for regenerative therapy showed its dark side, as many health concerns and ethical issues arose in terms of using these cells in clinical applications. In this regard, adult stem cells climbed up to the top list of regenerative tools and mesenchymal stem cells (MSC) showed promise for regenerative cell therapy with a rather limited level of risk. MSC have been successfully isolated from various human tissues and they have been shown to offer the possibility to establish novel therapeutic interventions for a variety of hard-to-noncurable diseases. There have been many elegant studies investigating the impact of MSC in regenerative medicine. This review provides compact information on the role of stem cells, in particular, MSC in regeneration.