Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response

<div>MSCs reduce infiltration of CTLs in the lungs of LLC1-treated mice and attenuate expression of FasL, perforin, and CD107 on their surface. Total number of (a) CD8+, (b) CD8+ FasL+, (c) CD8+ perforin+, (d) CD8+ CD107+, (e) CD8+ TNF-<i>α</i>+, and (f) CD8+ IL-17+ cells in the lungs of control, LLC1, and LLC1 + MSC-treated mice at the 28th day of the experiment, accompanied with representative dot plots. 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Stem Cells International

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Figure 4

Figure 4: Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response 