Stem Cells International / 2017 / Article / Fig 1

Review Article

Emerging Roles of MTG16 in Cell-Fate Control of Hematopoietic Stem Cells and Cancer

Figure 1

Schematic representations of MTG family proteins and their domain structures. The diagrams are drawn to scale and represent the exact binding domains between MTG proteins and other transcriptional regulators as determined by an extensive literature review. Many of the studies that examine the various MTG corepressor interactions focus on MTG8, and most demonstrate that the given interaction also exists in other MTG family members (MTG16 and MTGR1). In this figure, proteins written in black have been demonstrated to associate with both MTG8 and MTG16 (and MTGR1 in most cases). Proteins in red have been shown to interact with MTG8, but their interaction with MTG16 has never been directly tested. Proteins in blue have been specifically confirmed to interact with MTG8, but not MTG16. Finally, enclosing boxes denote proteins that have been shown to interact with MTG16 but have not been assessed for MTG8 binding.